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|本期目录/Table of Contents|

缺血心肌的脂质过氧化物损伤和临床应用抗氧化剂的价值(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1995年第3期
页码:
153-156
栏目:
论著
出版日期:
1995-05-01

文章信息/Info

Title:
Peroxidation damage of myocardial ischemia and clinical administration of antioxidants
作者:
黄新平1ⅹ 谭留明1 吴昌元1 王家翠2 邵文萍2
昆明医学院第一附属医院 1心内科 2中心实验室 昆明 650032
Author(s):
Huang Xinping; Liuming; Wu Changyuan; et al
Department of Cardiology,First Affiliated Hospital，Kunming Medical College，Kunming 650032
关键词:
心肌缺血; 氧自由基; 丙二醛; 超氧化歧化酶; 抗氧化剂
Keywords:
myocardial ischemia; oxygen free radical; malonaldehyde superoxide dismutase; antioxidants
分类号:
-
DOI:
-
文献标识码:
-
摘要:
取临床心肌缺血病例67例，予抗氧化剂治疗3个月；并于治疗前后检测其血浆超氧化歧化酶和丙二醛的浓度；超声心动图测定射血分数、快速充盈分值和左室后壁厚度；心电图观察缺血型ST段的变化情况，旨在研究氧自由基与心肌缺血的关系和抗氧化剂对缺血心肌的保护作用。结果表明：超氧化歧化酶浓度在心肌缺血的症状期降低，无症状期复升，并与射血分数和快速充盈分值的变化一致；丙二醛则无显著性改变，推测与其检测方法有关；临床表现有的抗氧化剂能消除症状，但不能使缺血性ST段和增厚的心室壁有明显的改观，推测其不具有阻断氧自由基生成的特异性抗氧化功能。
Abstract:
This study was designed to investigate the relationship between oxygen free radicals and ischemic myocardium，and the protective effects of antioxidants on the myocardium．Sixty-seven patients with myocardial ischemia were included and treated with antioxidants．Plasma concentrations of superoxide dismutase and malonaldehyde(MDA)were tested before and after the treatment．At the same time，echocardiography was employed to measure ejection fraction(EF)，rapid filling fraction and left ventricular posteiror wall thickness，and electrocardiography was used to observe changes in ST segments．The results showed that superoxide dismutase in all patients decreased during the symptomatic period and increased during the nonsymptomatic period，and the change was compatible with that in ejection fraction and rapid filling fraction．Antioxidants in use could clinically remove ischemicsymptoms but not bring about much improvement in ischemic ST segment and left ventricular posterior wall.MDA which was not signif icantly changed in this research Was presumably attributed to the method used，it was insensitive to the real plasma MDA Concentrations．

参考文献/References

［1］Roa PS．Parinam S．Mueller HS．et al．Production of free radicals and lipid peroxides in early experimental myocardial ischemia．J Md Cell Cardiol 1983；15：713.

［2］Guarnieri C，Flamigni F．Caldarera CM．Role of oxygen in the cellular damage induced by reoxygenation of hypoxic heart.J Md Cell Cardio l980；12：797.

［3］季健平．超氧化物歧化酶微量快速测定法．南京铁道医学院学报1991；l1)：77.

［4］齐凤菊,周 玫,陈 瑗.血浆丙二醛含量的测定方法:改良八木国夫法.第一军医大学学报1986；6(3)：157.

［5］傅良雄．过氧化脂质与冠心病．心血管病学进展 1988；9(1)：47.

［6］陈 瑷．周 玫．自由基医学．北京：人民军医出版社．1991；42．55～84.

［7］Gauduel Y．Duvelleroy MA．Role of oxygen radicals in cardiac injury due to reoxygenation.J Md Cell Cardiol Cell Cardiol l984；16：459.

［8］黄 宁,张淑雅,毛江森,等．甲型肝炎减毒活疫苗(H2减毒株)在人体接种的安全性观察．中华医学杂志 1990；70：683.

[9]韩雅玲．氧自由基与心力衰竭．国外医学心血管病分册1989；16(5)：290.

［10］rasad K．Kalra J．Oxygen free radicals and heart failure. Angiologt 1988；39(5)：417.

备注/Memo

备注/Memo:
Received 1994-05-27；revised 1995-02-07 ⅹ现在云南省红十字会医院心内科 昆明
更新日期/Last Update: 1995-05-01