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严重烧伤早期心功能抑制的体液机制Ⅰ烧伤血浆毒性物质对离体灌注豚鼠心脏功能的影响X(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1996年第2期
页码:
65-68
栏目:
论著
出版日期:
1996-03-01

文章信息/Info

Title:
he humoral mechnism of depressing cardiac functions in early stage after serious burn Ⅰ.The effect of the burned plasmic toxic substance on the cardiac functions
作者:
宋 涛1 萧家思2　阎淑枝2　侯　岷2　王铁丹3　萧应庆3
1军事医学科学院六所　2第三军医大学生理学教研室　重庆　630038 3第一军医大学生化教研室
Author(s):
Song Tao1;  Xiao Jiasi2;  Yan Shuzhi2;  Hou Min2;  Wang Tiedan3;  Xiao Ying qing3
1Sixth Institute,Academy of Military Medical Sciences 2Department of Physiology,Third Military Medical University , Chongqing 630038 3Department of Biochemistry, First Military Medical University
关键词:
烧伤;  毒素;  灌流;  心脏;  心室功能;  豚鼠
Keywords:
burn;  toxins;  perfusion;  heart;  ventricular function;  guinea pigs
分类号:
-
DOI:
-
文献标识码:
-
摘要:
作者从严重烧伤豚鼠血浆中提取出分子量在1.3～1.15 kD 的毒性物质(BPT) , 观察比较BPT及假伤(正常) 豚鼠血浆提取物(NPE) 对离体灌流正常豚鼠心脏功能的影响。结果发现: 高、中、低3种浓度BPT; ①对心脏有明显的抑制作用, 表现在左室内压及其变化率明显降低, 高浓度BPT 可使心率减慢, 出现心律失常, 心脏可迅速停止于舒张期; ②使冠脉收缩, 冠脉流量减少; ③明显降低心肌氧耗量, 抑制心肌线粒体的功能; ④高浓度的NPE有相当于低浓度BPT的生物效应。
Abstract:
A tox ic substance with molecular weight about 1.3～1.5 kD was extracted from blood plasma of burned guinea-pigs (BPT). The effects of this toxic extract on the cardiac functions of isolated heart of normal guinea-pigs were observed and compared with those of plasmic extract(NPE)of pseudo-injury (normal) animals.The result showed as follow s:1.All of the high, middle and low concentractions of BPT possessed an obvious inhibitory effect on the heart, i.e.they could evidently decrease the left intraventricular pressure(LVP)and it′s alteration rate(dp/dtmax).BPT in high concen-tration slowed the heart rate and evoked the arrhythmia.The heart beat may arrest in diastole rapidly.2.BPT constricted the coronary arterioles and reduced the coronary flow.3.BPT decreased the oxygen consumption and depressed respiratory functions of the myocardial m itochondria.4.The biological effect of the NPE in high concentration corresponded with that of BPT in low concentration.

参考文献/References

［1］Moati F, Sepulchre C, M iskulin M , et al.Biochemi-cal and pharmacological properties of a cardiotoxic factor isolated from the blood serum of burned pa-tients.J Pathol 1979; 127 (3) : 147.

［2］李 靖, 萧家思, 侯　岷. 烧伤对豚鼠离体灌流心脏收缩及舒张功能的影响.第三军医大学学报 1990; 12 (6) : 480.

［3］Markelov ZM , Vikhriev BS, Tupikova ZA, et al. Content of middle mass molecules in blood serum of patients with burns after hemosorption treatment.Vopr Med Khim 1983; 29 (3) : 105.

［4］Tupikova ZA. Effect of middle mass molecules from blood sera of patients with burns on the process of lipid preoxidation. Vopr Med Khim 1983; 29 (3) : 108.

［5］李 靖, 萧家思.小哺乳动物心脏顺行性离体灌流技术.第三军医大学学报 1990; 12 (5) : 424.

［6 叶本兰, 萧家思.烧伤血浆中分子物质对豚鼠心肌线粒体膜流动性的影响.中国应用生理杂志 1992; 8 (4) : 369.

［7］叶本兰, 萧家思, 阎淑枝.烧伤血浆毒性物质对豚鼠心肌线粒体功能的影响.四川生理学杂志 1994; 16 (4) :.

备注/Memo

备注/Memo:
Received 1995-06-29； revised 1996-01-25 国家自然科学基金资助项目 编号：3883401
更新日期/Last Update: 1996-03-01