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|本期目录/Table of Contents|

冲击伤对大鼠心脏功能的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1996年第2期
页码:
73-76
栏目:
论著
出版日期:
1996-03-01

文章信息/Info

Title:
Effect of blast in jury on cardiac functions of rats
作者:
阎淑枝　萧家思　侯　岷
第三军医大学生理学教研室　重庆　630038
Author(s):
Yan Shuzhi;  Xiao Jiasi;  Hou Min
Department of Physiology, Third Military Medical College,Chongqing 630038
关键词:
冲击伤;  灌流;  离体心脏;  心功能;  大鼠
Keywords:
blast injury ;  perfused;  isolated heart;  cardiac function;  rats
分类号:
-
DOI:
-
文献标识码:
-
摘要:
作者用Wistar大鼠70只, 随机均分为7组, 除正常对照组外, 其余6组用BST-1型生物激波管致闭合式单纯超压伤。观察幸存大鼠伤后8 h到15 d过程中6个时相点离体灌流工作心脏功能的变化。与对照值相比: 伤后8 h 心率减慢至54% , 心缩及心舒期分别延长到1.5和2.0倍; 左室内压、+dp/dtmax和-dp/dtmax分别降至54%、32%、42%; 伤后1周, 心率维持在60% 左右, 心缩期进行性地延长, 可长达1.9倍, 心舒期维持在1.6～1.7 倍; 左室内压及其变化率维持在46%～61%; 伤后15 d心功能主要指标可恢复到或接近于正常对照水平, 自律性恢复早于收缩性的恢复。因此, 心脏保护措施宜及早进行, 且持之以恒。
Abstract:
The effect of blast injury on the functions of isolated heart was studied in 70 Wistar rats weighing 200～ 250 g. The animals were randomly and equally divided into 7 groups: one group was the normal controls , the rats in other 6 group s suffered simple overpressure injury caused by the BST-1 model biological shock tube. The experiments were performed at 8 h, 1, 3, 5, 7 and 15 days respectively after the blast injury.The results were shown as follows. 1. The heart rate was slowed down to 54% of the control value at 8 h after injury.The systole and diastole were prolonged to 1.5 and 2.0 times of the no rmal control, respectively. The left intraventricular pressure (LVP), + dp/dtmax , - dp/dtmax were also decreased to 54% , 32% and 42% , respectively; 2. 1 week after the blast injury, the heart rate remained in about 60% of the control value. The systole was prolonged progressively and up to 190% of the control level. The diastole maintained 1.6～ 1.7 times of the norm al value. The LVP and ±dp/dtmax recovered gradually to 46%～ 61% of the normal level.3.Half a month after injury, the cardiac functions may be recovered to or near the normal control level. The restoration of m yocardial rhythmicity was earlier than that of the contractility.Thus, the protective treatment of the cardiac function should be performed as early as possible for more than two weeks。

参考文献/References

［1］王正国.冲击伤.北京: 人民军医出版社,1983: 165 .

[2]Damon EG.Acute effects of air blast on pulmonary function in dogs and sheep1.Aerosp Med 1971; 42.

[3]林 远, 程天民, 王德文.烧冲复合伤心脏病理化的实验研究.解放军医学杂志1992; 7 (4) :193.

[4]林远, 程天民.冲击伤超压所致速发死亡大鼠的心脏病理变化.第三军医大学学报1993;15 (2) : 141.

[5]孙立英, 王正国.小型生物激波管的研制及其初步应用.第三军医大学学报1991; 13 (3) : 270.

[6]阎淑枝,萧家思,侯　岷.高钙对严重烧伤大鼠体灌流心脏固有收缩性的影响.基础医学与临床1991;11 (5):37.

［7］李 靖, 萧家思.烧伤对离体灌流豚鼠心脏收缩及舒张功能的影响.第三军医大学学报1990; 12 (6) : 480.

备注/Memo

备注/Memo:
Received 1995-02-10；revised 1995-12-05
更新日期/Last Update: 1996-03-01