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严重烧伤早期心功能抑制的体液机制Ⅱ烧伤血浆毒性物质对离体豚鼠乳头肌电活动的影响 ＊(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1996年第3期
页码:
129-133
栏目:
论著
出版日期:
1996-05-01

文章信息/Info

Title:
he humoral mechanism of depressing cardiac functions in early stage of serious burn Ⅱ. Effects of burned Plasmic toxic substance on electric activity of isolated guinea pig′s paillary muscle
作者:
宋　涛1＊＊ 肖家思1　阎淑枝1　侯　岷1　王铁丹2　肖应庆2
1第三军医大学生理学教研室　重庆　630038　2第一军医大学生化教研室 广州510515
Author(s):
Song Tao1＊＊;  Xiao Jiasi1;  Yan Shuzhi1;  Hou Min1;  Wang Tiedan2;  Xiao Yingqing2
1Department of Physiology, Third Military Medical University, Chongqing 630038 2Department of biochemistry, First Military medical University, Guangzhou 510515
关键词:
烧伤;  毒素;  动作电位;  乳头肌;  豚鼠
Keywords:
burn;  toxins;  action potential;  papillary muscles;  guinea pigs
分类号:
-
DOI:
-
文献标识码:
-
摘要:
作者观察了严重早期烧伤及假伤(正常) 血浆提取物(分别以BPT及NPE表示) 对离体灌流正常豚鼠乳头肌细胞电活动的影响。结果发现: 高、中、低3种浓度的BPT, ①均可使静息电位减小, 其时程曲线略呈“S”形, 其潜伏期有明显的浓度依赖性; ②均可引起乳头肌节律不整的自发兴奋; ③高浓度BPT 明显使动作电位幅度(APA) 降低, 中、低浓度的BPT对APA及最大除极速度均无明显影响; ④BPT对复极化时程APD10的影响不大, 但使APD50及APD90显著延长, 使动作电位波形在复极化初期出现明显的凹陷和平台期延长; ⑤高浓度NPE有相当于低浓度BPT的生物效应。提示BPT 可能直接影响心肌细胞K+ 、Ca2+ 的转运, 对Na+ 的离子转运影响较小。
Abstract:
The effects of plasma extract of normal(NPE)and burned(BPT)guinea pigs on bioelectric activity of isolated normal gu1inea pig′s papillary muscle were observed and compared.The burned animals suffer for35%full thickness burn injury.After 8h the results are shown as follows. 1. All BPT of high, middle and low concentrations and NPE in high concentraton sygnif icantly decrease the resting potential (RP). The variation of time course of RP expresses as the shape of“S”. There is an obvious concentration dependence for the response latency. 2. The arrhythmic spontaneous excitation may be evoked by either BPT of three concentrations or NPE in high concentration. 3. The high concentration of BPT decreases the amplitude of action potential (APA) obviously, other BPT concentrations and all NPE have no effect on APA and maximal depolarization rate (Vmax). 4. Both BPT and NPE have no effect on 10% repolarization duration (APD10) , but BPT obviously prolonged the 50% and 90% repo larization duration(APD50, APD90) respectively. The waveform of the action potential showed an obvious concave at early repo larization course and a prolonged plateau. 5. The biological effect of NPE in high concentration corresponds with that of BPT in a low concentration. These results suggest that BPT may be able to directly influence the transport of K+ and Ca2+ and may have little effect on Na+ transport across the cell membrane.

参考文献/References

［1］何庆加, 肖家思, 张问德, 等. 烧伤大鼠在体心室肌细胞跨膜电位的变化. 中华整形烧伤外科杂志1988; 4 (3) : 212.

［2］Xiao JS, He QJ , Zhang Y, et al. Comparison of ventricular cell action potential of combined radiation-burn injury with that of rediation or burn injury in rats. J Med Coll PLA 1988; 3(3) : 275.

［3］宋 涛, 肖家思, 阎淑枝. 严重烧伤早期心功能抑制的体液机制: é. 烧伤血浆毒性物质对离体灌流豚鼠心脏功能的影响. 心功能杂志1996; 8(2) : 65.

［4］叶本兰, 肖家思, 阎淑枝. 烧伤血浆毒性物质对豚鼠心肌线粒体功能的影响. 四川生理学杂志1994; 16 (4) : 1.

［5］Liu YM , Huang ZQ , Xiao JS, et al. Measurement of guinea-pigs intracellular K+ concentration with potassium microelect rodes. J Electrochem Soc 1992; 139 (3) : 820.

［6］Naruak iN , Shinichi K, Morio K, et al. Intracellular K+ and Na+ activities underhypoxia,acidosis , and no glucose in dog hearts. Am J Physiol 1985; 249: H1078.

［7］Gunnar A. Why do ischemic and hypoxia myocardium lose potassium? J Mol Cell Cardiol1992; 24 (3) : 323.

备注/Memo

备注/Memo:
Received 1995-08-29；revised 1996-01-25 国家自然科学基金资助课题 编号：3880341＊＊现在军事医学科学院毒物药物研究所 北京 100850 Now Address: Institute of Pharmacology and Toxicology,Beijing 100850
更新日期/Last Update: 1996-05-01