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降钙素基因相关肽的抗室颤作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1997年第1期
页码:
5-7，10
栏目:
论著
出版日期:
1997-01-01

文章信息/Info

Title:
Antiarrhythmic effect of calcitonin gene-related peptide
作者:
李红梅X 　裴建明　朱妙章　牛国保　臧益民
第四军医大学生理学教研室　西安 710032
Author(s):
Li Hongmei;  Pei Jianming ;  Zhu Miaozhang ;  Niu Guobao and Zang Yimin
Department of Physiology, Fourth Military Medical University, Xi′an 710032
关键词:
降钙素基因相关肽类　心室纤颤　心肌梗塞　再灌流损伤
Keywords:
　calcitonin gene-related peptide ventricular fibrillation　　myocardial ischemia　　reperfusionin jujury
分类号:
-
DOI:
-
文献标识码:
-
摘要:
作者用电脉冲刺激家兔心脏引致室颤发生, 在麻醉兔心肌缺血再灌注模型上观察降钙素基因相关肽(CGRP) 对正常及心肌缺血再灌注后室颤时间的影响。结果显示, 高于室颤阈的电脉冲刺激可致家兔心脏发生室颤, 继而自行恢复为正常心律。静注CGRP(2.5 Lg/kg) 后, 血压和心率无明显的变化, 室颤时间明显缩短(P<0.01)。结扎冠脉后, 室颤时间明显延长(P<0.01) ; 松扎后再灌注期可见室颤时间恢复到明显低于正常水平。结扎冠脉及松扎同时均注射CGRP, 发现室颤时间较对照组显著缩短(P<0.01)。该实验结果说明: CGRP具有较强的抗室性缺血性心律失常的能力, 因而具有一定的临床意义。
Abstract:
In this study, with a model of the myocardial ischemia and reperfusion in anesthetized rabbit, we observed the effect of calcitonin gene-related peptide(CGRP) on ventricular fibrillation duration(VFD)after normal and myocardial ischemia or/and reperfusion theventricular fibrillation (VF)was induced by electric stimulating the rabbit heart. The results showed that VF developed immediately after the electrical stimulation that was over VF threshould, and the normal rhythm recovered automatically after a while. The blood pressure and the heart rate had no significant changes while the VFD was shortened obviously after I.V..CGRP (2.5 Lg/kg) (P<0.01).In the ischemic period after coronary artery ligation, the VFD was prolonged obviously (P<0.01),but in the reperfusion period after coronary artery reopening, the VFD was shortened and was much shorter than that of the normal. It was found that the VFD was significant shortened compared with the control after the coronary artery ligation and reopening with the I. V. administration of CGRP simultaneously. These data suggest that CGRP is strongly effective against ischemic ventricular arrhythmia and this may have certain clinical significance.

参考文献/References

［1］Packer M. Lack of relation between ventricular arrhythmias and sudden death in patients with chronic heart failure. Circulation, 1992; 85: Ⅰ-50.

[2]裴建明, 周士胜, 牛国保, 等. 氯化四乙基铵及维拉帕米对家兔缺血心肌不应期的影响.药学学报, 1992; 27 (10) : 721.

[3]汤树本, 侯悦颜, 国润泽, 等.α与β受体在枸橼酸钠所致家兔室颤中的作用. 生理学报,1982; 34: 483 .

[4]李红梅, 裴建明, 朱妙章, 等. CGRP对缺血心肌保护作用的实验研究. 心电学杂志, 1993;12 (2) : 126.

[5]裴建明, 李红梅, 牛国保, 等. 降钙素基因相关肽对犬心肌血液流变学的影响. 中华心血管病杂志, 1993; 21 (1) : 42.

[6]王 宪, 韩启德. 降钙素基因相关肽(CGRP):一种新发现的有强大心血管作用的神经肽. 生理科学, 1989; 9 (1) : 1.

[7]裴建明, 臧益民, 朱妙章, 等. 降钙素基因相关肽拮抗垂体后叶素引起心肌缺血性电生理改变的观察. 心脏起搏与心电生理杂志, 1995; 9 (2) : 91.

［8］汤　健, 唐朝枢, 主编. 心肺内分泌学. 北京: 科学技术出版社, 1991: 192～ 193.

备注/Memo

备注/Memo:
Received 1995-05-24；revised 1995-10-17 X现在西安市解放军323医院心内科 西安 710054
更新日期/Last Update: 1997-01-01