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等容血液稀释和超氧化物岐化酶对兔缺血/再灌注心肌的保护(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1997年第1期
页码:
11-14
栏目:
论著
出版日期:
1997-01-01

文章信息/Info

Title:
The effects of isovolumetric hemodilution and superoxide dismutase on ischemic reperfused hearts in the rabbit
作者:
李秀莲1　王柏生　汤　宁　吕杰胜　黄幼田
河南医科大学病理生理教研室　郑州 450052
Author(s):
Li Xiulian;  Wang Baisheng ;  Tang Ning ;  Lu Jjesheng and Huang You tian
Li Xiulian, Wang Baisheng , Tang Ning , Lu Jjesheng and Huang You tian
关键词:
心肌缺血　再灌注损伤　血液稀释　血液动力学　右旋糖酐类　超氧化物岐化酶
Keywords:
myocardial ischemia　　reperfusion injury　hemodilution　　hemodynamics　　dextrans　　superoxide dismutase
分类号:
-
DOI:
-
文献标识码:
-
摘要:
结扎兔冠脉左室枝45 min, 再灌注180 min, 复制急性心肌缺血/再灌注模型, 观察等容血液稀释和超氧化物歧化酶(SOD) 对兔心肌缺血/再灌注损伤保护的协同作用并探讨其可能的机制。40只动物随机分为4组: Ⅰ组(对照组)、Ⅱ组(稀释组)、 Ⅲ组(SOD组) 和 Ⅳ组(稀释+ SOD 组)。结果: 与Ⅰ组比,Ⅱ, Ⅲ组左室收缩功能(最大收缩压、+ dp/dtmax)显著改善, Ⅳ组较Ⅱ, Ⅲ组又有显著改善。与Ⅰ组梗塞面积(左室梗塞面积占左室总面积的百分比为18.1±2.3%) 比, Ⅱ , Ⅲ, Ⅳ组梗塞面积显著缩小(分别为11.4±2.1% ,13.8±2.2% , 8.3±2.9%) , Ⅳ组梗塞面积较Ⅲ组又有进一步缩小(P<0.05)。提示: 等容血液稀释和SOD对兔缺血/再灌注心肌均有保护作用; 两者联用可进一步改善左室收缩功能和缩小梗塞面积。
Abstract:
Isovolumetric hemodilution treatment reduces ischemic injury, and superoxide dismutase (SOD )may reduce reperfusion injury. However, the effects of simultaneous treatment with both interventions have never been investigated. In the present study, anesthetized rabbits underwent 45 min of coronary artery ligation, which was followed by 180 min of reflow. Ten animals in each group recieved: ①saline solution only; ②hemodilution with dextran 40 during ischemia; ③SOD before and during reperfusion; ④combined treatment with hemodilution and SOD. Left ventricular peak pressure (LVP)and + dp/dtmax was improved significantly during reperfusion in hemodilution group and SOD group and myocardial systolic functions were improved further in hemodilution+SODgroup as compared with that in controls. In control rabbits infarct size (percentage of the infarct size to the total left ventricle) averaged 18.1±2.3%.In contrast, infarct size was significantly reduced by either hemodilution treatment (11.4±2.1% , P<0.05) or SOD administration (13.8±2.2% , P<0.05). Further reduction of infarct size was observed in hemodilution+SOD group (8.3±2. 9% , P<0.05) as compared with that in hemodilution group. The results suggested that combination of the two interventions would improve left ventricular systolic functions and reduce infarct size further and showed a better protective effect on reperfused myocaridum.

参考文献/References

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备注/Memo

备注/Memo:
Received 1996-02-06 X现在地址：秦皇岛市第一医院心内科
更新日期/Last Update: 1997-01-01