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|本期目录/Table of Contents|

缓激肽对兔顿抑心肌功能的保护作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
1998年第4期
页码:
219-220,224
栏目:
论著
出版日期:
1998-07-01

文章信息/Info

Title:
The protective effect of bradykin in on the function of stunned myocardium in rabbit
作者:
李 飞　贾国良　梁延春　李 伟
第四军医大学西京医院心内科 西安 710032
Author(s):
Li Fei;  Jia Guoliang ;  Liang Yanchun;  Li Wei
Department of Cardiology, Xijing Hospital, The fourth Military Medical University, Xi′an 710032
关键词:
缓激肽　心室功能　心肌缺血
Keywords:
bradykinin　ventricular function　myocardial ischemia
分类号:
-
DOI:
-
文献标识码:
-
摘要:
本文报道缓激肽(BK) 对兔顿抑心肌功能的作用。结果显示: 结扎兔冠脉左室支15 min, 再灌注30 min,左室收缩及舒张功能进行性下降; 结扎前左室内灌注生理盐水对顿抑心肌功能无明显影响; 结扎前左室内灌注缓激肽后, 再灌注30 min 时左室功能恢复至正常水平。提示: 缓激肽对兔顿抑心肌的功能具有保护作用。
Abstract:
The article reports the effects of bradykinin on the function of stunned myocardium in rabbits in vivo. In our experiment, in the untreated group and saline treated group , the indexes of left ventricular function reduced significantly after occlusion of the left ventricular artery and continue to reduce after reperfusion. The 10 min infusion of bradykinin attenuates the dysfunction after 30 min reperfusion. The result indicates that bradykinin can attenuate the stunned myocardium dysfunction.

参考文献/References

［1］Bolli R. Mechanism of myocardial “stunning ”. Circulation,1990; 82 (3) : 723.

［2］Homans DC, Sublett E, Dai XZ. Persistence of regional left ventricular dysfunction after exercise-induced myocardial ischemia.J Clin Invest, 1986; 77 (1) : 66.

［3］Visser CA , David GK, Kan G, et al. Two dimensional echocardiography during percutaneous transluminal coronary angioplasty. Am Heart J , 1986; 111: 1035.

［4］ Lin ZW , Wiemer G, Scholkens BA. Role of kinins in the pathophysiology of myocardial ischemia. In vitro and vivo studies.Diabetes, 1996; 45 (Suppl) : S51.

[5]Ehring T, Baumgart D, Krajcar M. Attenuation of myocardial stunning by the ACE inhibitor ramiprilat through a signal cascade of bradykinin and prostaglandins but not nitric oxide. Circulation, 1994; 90 (3) : 1368.

［6］Hattler BG, Gorcsan J , Shan N. A potential role for nitric oxide in myocardial stunning. J Cardiovasc Surg , 1994; 93 (Suppl) :425.

备注/Memo

备注/Memo:
((收稿1998-03-24　修回1998-04-30)
更新日期/Last Update: 1998-07-01