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|本期目录/Table of Contents|

不稳定性心绞痛与血管活性肽的相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第3期
页码:
172-173
栏目:
论著
出版日期:
2000-05-25

文章信息/Info

Title:
The relation of plasma vasoactive peptide concentration with UAP
作者:
王文清;  刘朝中;  谈维洁;  孙晓丽;  黄从春;  毛树森;  江一清
空军总医院心血管内科, 北京100036
Author(s):
WANG Wen-qing; LIU Chao-zhong; TAN Wei-jie; SUN Xiao-li; HUANG Cong-chun; MAO Shu-sen; JIANG Yi-qing
Department of Cardiology, Airforce General Hospital, Beijing 100036, China;
关键词:
心绞痛;  不稳定型;  血浆内皮素;  降钙素基因相关肽;  神经肽Y;  P 物质
Keywords:
angina;  unstable;  endothelin;  calcitonin gene related peptide;  neuropeptide Y;  substance P
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨不稳定性心绞痛(UA P) 与血管活性肽的相关性。方法 观察42 例UA P 患者心绞痛发作前后血浆内皮素(ET )、降钙素基因相关肽(CGRP)、神经肽Y (N PY) 及P 物质(SP) 的变化, 并和20 例正常人对照。结果 当心绞痛发作时,UA P 患者血浆ET ,N PY, SP 均较前明显升高(P < 0. 05) , CGRP 含量下降; 随着心绞痛的缓解,血浆CGRP 开始升高, ET ,N PY 和SP 均于3 d 后恢复至发作前水平。结论 UA P 的发生与血管活性肽的变化密切相关, 血管活性肽对维持冠脉舒张和循环有重要意义。
Abstract:
AIM To probe into relation beween unstable angina pectoris (UAP) and vasoactive peptide. METHODS We investigated the variation of plasma concentration of endothelin (ET), calcitonin gene related peptide (CGRP),neuropeptide Y (NPY) and substance P (SP) in 42 patients with UAP and 20 healthy subjects. RESULTS When angina pectoris attacked ET,NPY,SP increased ( P <0.05). Concentration of CGRP decreased. After angina pectoris was relieved,ET,NPY and SP concentration decreased to pre-angina pectoris level in 3 days but CGRP concentration was still high. CONCLUSION The variation of plasma vasoactive peptide concentration was not only related to UAP attack but also significant to the maintance coronary diastole and corculation.

参考文献/References

［1］ Lidon TP. Unstable angina: Pathogenesis, diagnosis and treatment[J]. Curr Probl Cardiol, 1993, 18 (3) : 163.

[2] Lee RT, Schoen FJ. Pathology of unstable coronary plaque[A ]. Rutheroford JD. Unstable angina [M ]. New York: Marcel Dekker. Inc, 1992: 22.

[3] 黄益萍. 充血性心力衰竭患者血浆内皮素R IA [J ]. 放射免疫学杂志, 1996, 9 (1) : 20.

[4] Ogawa T. Platelet neuropeptide Y in spontaneously hypertensive rats[J ]. J Hypertension, 1992, 10 (8) : 765.

[5] Lechleitner P, Genser N. Calcitonin gene related pep tide in patients with and without early reperfusion after acute myocardial infarction[J]. Am Heart J , 1992, 124 (6) : 1433.

备注/Memo

备注/Memo:
收稿日期：1999-12-08.
更新日期/Last Update: 2000-05-25