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心脏肌钙蛋白I 诊断急性心肌梗死的价值(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第3期
页码:
177-178
栏目:
论著
出版日期:
2000-05-25

文章信息/Info

Title:
Diagnostic value of cardiac troponin Ⅰ in acute myocardial infarction
作者:
姜昌浩1;  叶国良1;  洪小飞2
义乌市人民医院: 1 心内科, 2 ICU , 浙江义乌322000
Author(s):
JIANG Chang-hao1;  YE Guo-liang1;  HONG Xiao-fei2
Yiwu People′s Hospital, Yiwu 322000, Zhejiang, China
关键词:
心肌钙蛋白I;  心肌梗死;  心绞痛;  溶栓
Keywords:
cardiac troponin I;  myocardial infarction;  angina;  thrombolysis
分类号:
R542.2
DOI:
-
文献标识码:
A
摘要:
目的 探讨血清心脏肌钙蛋白I(cTnI) 在急性心肌梗死(AM I) 中的诊断价值。方法 急性心肌梗死(AM I) 组患者20 例, 不稳定型心绞痛(UA)组31例, 陈旧性心肌梗死(OMI) 组11例, 危重病患者87例(非心血管疾病)。AMI组患者系列采血测定血清cTn I 和CK2MB,UA 与OMI 组、危重患者组均入院后次日晨取血1次。结果 cTnI与CK2MB 诊断AMI的敏感性均为100% , cTnI 诊断AMI的特异性高于CK2MB (P <0.05) ;AMI时cTnI浓度高峰时间与CK2MB 平行, 持续时间明显延长(P<0.01) , 溶栓患者高峰时间明显前移(P< 0.01)。结论 cTnI 诊断AMI敏感性高, 其特异性高于CK2MB。且在血清中出现早且持续时间长。其峰值时间改变可用于判定AMI的溶栓疗效。
Abstract:
AIM To explore the diagnostic value of serum cardiac troponin I(cTnI) in acute myocardial infarction(AMI) patients. METHODS The patient population consisted of 20 AMI patients,31 unstable angina patients,11 OMI patients and 87 critical patients with non cardiovascular diseases. Blood samples were collected serially in AMI patients and once on second morning after admission in the others. RESULTS The sensitivity of cTnI or CK MB to diagnosing AMI was 100%. The specificity of cTnI was higher than that of CK-MB (P<0.05).The time to peak value fo r cTnI w as 8～ 48 h after onset of symptom respectively and the curve line was parallel to that of CK-MB. The time of cTnI elevation lasting 10～ 12 days was longer than that of CK-MB (P<0.01). The time to peak value was moved up obviously in thrombolyt is group (P<0.01). CONCLUSION CTnI is a highly sensitive marker for diagnosing AMI and its specificity is higher than that of CK-MB. It appears early and last long. The change of the time to the peak of cTnI can predict the efficiency of thrombolysis in AMI patients.

参考文献/References

［1］ Cummins B,Aucklan dM, Cummins P. Cardiac-specific troponin I, radioimmunoassay in the diagnosis of acute myocardial infarction[J ]. Am Heart J , 1987, 113 (6) : 1333.

[ 2 ] Adamas JE, Bodor GS,Davila-Roman VG. Cardiac troponin I: a marker with high specificity for cardiac injury [J ]. Circu lation,1993, 88 (1) : 101.

[ 3 ] 李　静, 胡大一, 顼志敏, 等. 血清心脏肌钙蛋白I 在急性心肌梗塞中的临床价值[J ]. 中国循环杂志, 1999, 14 (9) : 42.

[ 4 ] 张寄南, 杨国平, 苏恩木, 等. 血清肌钙蛋白I 诊断急性心肌梗塞的研究[J ]. 中华心血管病杂志, 1997, 25 (5) : 379.

备注/Memo

备注/Memo:
收稿日期：1999-12-24.
更新日期/Last Update: 2000-05-25