我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

尼莫地平对动脉压力感受器反射的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2000年第5期
页码:
369-371
栏目:
论著
出版日期:
2000-10-25

文章信息/Info

Title:
Effect of nimodipine on arterial baroreflex in humans
作者:
侯立朝1;  毕好生2;  王芙蓉2;  熊利泽1
1. 第四军医大学西京医院麻醉科, 陕西西安710032; 2. 同济医科大学同济医院麻醉科, 湖北武汉430032
Author(s):
HOU Li-chao1;  BI Hao-sheng2;  WANG Fu-rong2;  XIONG Li-ze1
1. Xijing Hospital, Fourth Military Medical University, Xian Shaanxi 710032, China; 2. Tongji Hospital, Tongji Medical University, Wuhan Hubei 430032, China
关键词:
尼莫地平; 动脉压力感受器反射
Keywords:
nimodipine;  arterial baroreflex
分类号:
R614
DOI:
-
文献标识码:
A
摘要:
目的 探讨尼莫地平(nimodipine)对动脉压力感受器反射的影响。方法 20例ASA I～II级、拟在全麻下施行胆囊切除手术的患者，随机分为尼莫地平组（NM组）和对照组（C 组），每组10例。在麻醉前及麻醉手术开始后分别静注新福林或硝酸甘油进行加压试验或减 压试验。观察用药前后血压、心率的变化。用心动周期和动脉收 缩压变化量的线性回归斜率来反映动脉压力感受器反射敏感度。结果 在C组患者，加压反射 的斜率由麻醉前的89.1 ms/kPa降到麻醉手术期的46.9 ms/kPa（P＜0.05），减压反射的 斜率 由麻醉前的81.9 ms/kPa降到麻醉手术期的36.7 ms/kPa(P＜0.05)；NM组患者，加压反射 和减 压反射的斜率分别由麻醉前的55.9 ms/kPa和57.4 ms/kPa降到麻醉手术期的31.2 ms/kPa和2 3.5 ms/kPa (均P＜0.05)；NM组患者在麻醉前、麻醉手术期的加压反射和减压反射的斜 率与C 组患者比较均有轻微的降低，但无统计学显著性。 结论 小剂量尼莫地平对动脉压力感受器反射有轻度 抑制作用。临床常用剂量的尼莫地平应用于麻醉手术期是安全的。
Abstract:
AIM To study the effect of nimodipine on arterial barore flex. METHODS Twenty patients with ASA physical status I～II, scheduled for cholestectomy und er g eneral anesthesia, were randomly divided into nimodipine group (Group NM, n= 10) and control group (Group C, n=10). Pressor test and depressor test with int raven ous phenylephrine and nitroglycerin were carried out both before and anesthesia and during the operation, and changes in arterial blood pressure, heart rate were also recorded.Arterial baroslope was acquired by line regression of R-R interv a l from electrocardiogram and changes in arterial systolic blood pressure.RESULTS In Group C and group NM the baroslope of pressor test decreased from 89.1 ms·kPa-1 and 55.9 ms·kPa-1 before anesthesia to 46.9 ms·kPa-1 and 31.2 ms·kPa-1 during operation respectively(P＜0.05), and the baroslope of depressor test decreased from 81.9 ms·kPa-1 and 57.4 ms·kPa-1 before anesthesia to 36.7 ms·kPa-1 and 23.5 ms·kPa-1 during operation respectively (P＜0.05); The baroslope o f pre ssor test and depressor test before anesthesia and during operation were both sl ightly decreased in Group NM, compared with that in Group C, but with no statist ic ally significance. CONCLUSION A small dose of nimo dipine had a slight inhibitive action on arterial baroslope. Clinical dose of nimodipine could be safely used during anesthesia and operation period.

参考文献/References

［1］ Kazda S, Gerthoff B,Krause HP,et al. Cerebrovascular effects o f the calcium antagon istic dihydroperidine derivative nimodipine in animal experiments［J］.　Arzne imittel Forschung，1982，32:331.

［2］ 张均田.钙通道拮抗剂1,4双氢吡啶类第二代新药-尼莫地平［J］. 中国药理学通报, 1987,3:235.

［3］ Adent P, Fesard P,Riegel B,et al. Interaction of nimodipine and isoflu ra ne in surgery of intracranial aneurysm［J］. Agressologie, 1989,30(7):399.

［4］ Schwartz AE, Maneksha FR,Backus WW,et al.Nimodipine decreases the mini mum alveol ar concentration of isoflurane in dogs［J］. Anesth Analg， 1990，70:S356.

［5］ Bormann B, et al.Calcium antagonists and analgesia［J］. Intensive C are Medicine(Supplement), 1986,12:263.

［6］ Huyghens LP, Buylaert WA,Corne L,et al. Plasma concentrations and haem odynamic effect of nimodipin e in patients resuscitated after cardiac arrest［J］. Eur J Clin Pharmacol， 1989，36(4):327.

［7］ Duncker DJ, Saxena PR,Verdouw PD,et al.Systemic haemodynamics of dihyd ropyridine derivatives in conscious pigs with or without propranolol［J］. Eur J Pharmacol， 1988;156( 3):401.

［8］ Boldt J, Von Bormann B,Kling D,et al. Hemodynamic effects in high-dos e infusion of nimodipin e, a new calcium antagonist［J］.　Anasth　Intensivthe r　Notfallment， 1986，21(5):245.

［9］ Scriabine A, Van-den-kerckhoff W.Pharmacology of nimodipine, a review［ J］. Ann N Y Acad Sci， 1988;522:698.

备注/Memo

备注/Memo:
收稿日期：1999-10-25.
更新日期/Last Update: 2000-10-25