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精氨酸加压素受体拮抗剂在实验性充血性心力衰竭中的作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第1期
页码:
16-18
栏目:
论著
出版日期:
2001-01-25

文章信息/Info

Title:
Role of arginine vasopressin receptor antagonist in experimental congestire heart failure
作者:
边长勇; 秦永文; 郑兴; 章同华
第二军医大学附属长海医院心内科，上海 200433
Author(s):
BIAN Chang-yong; QIN Yong-wen; ZHENG Xing; ZHANG Tong-hua
Department of Cardiology．Changhai Hospital，Second Military medical University，Shanghai 200433，China
关键词:
心力衰竭; 充血性; 精氨酸加压素受体拮抗剂; 血流动力学; 心脏功能; 大鼠
Keywords:
heart failure; congestive; argnine vasopressin receptor antagonist; hemodynamics; car diac function; rat
分类号:
R541.61；R972
DOI:
-
文献标识码:
A
摘要:
目的 探讨精氨酸加压素受体拮抗剂在慢性充血性心力衰竭中的作用。方法 大鼠左冠拮扎，造成左室大面积梗死，存活10周。行左心室、股动脉、股静脉插首，铡定其收靖压(SBP) 舒张压(DBP) 平均动脉压(MBP) 左心室压峰值(LVSP) 左室舒张末期压(LVEDP)，左室内压最大上升建事(+dp／d 。)，左室内压最大下降莲率(-ap／dr． )。收靖期心力环(L(1+2))，舒张期心力环(L(3+4)) 总心力环(Lo)聂心事(HR)。LVEDP>2 k 大鼠随机分为 ①心寰给精氨酸加压素(AVP)V1／VZ受体拈抗荆组I圆心寰蛤50 g／L葡萄糖(Gs)组．另设@假手术组．静注v1／V2受体拮抗荆．3组大鼠测定蛤药前聂给药后10。2o，30，柏．6O．90。120min时问点血赢动力学聂心肌舒培功能指标．结果 心衰大鼠静注AVPV1／VZ受体拮抗剂，对血压和心率无明显影响。用药20 rain后-LVEDP啊显下降．井持续到实验结柬。30min时+dp／d￡一聂一 ，df一明显增加，井于40 rain时升至最大．伴有L(1+2) L(3+4)和Lo的明显增加。结论 心衰大鼠静注AVP V1／V2受体拮抗剂后，心肌的收靖 舒张功能得以改善．对充血性心衰有一定的治疗作用。
Abstract:
AIM To investigate the role of arginine vasopressin (AVP)receptor antagonist in chronic congestive heart failure．METHODS The 1eft coronary artery was 1igated to produce a large infarct on the left ventricle,and the rat survived for 10 weeks． I eft ventricle，arteria femoralis and femoral vein were cannulated to measure the SBP．DBP，MBP，LVSP，LVEDP，+dp／dt ，-dp／dt ，L(1+2)，L(3+4)，Lo and HR．The rats with LVEDP > 2 kPa were ran— domly divided into 2 groups：①The group of rats with heart failure received AVP Vl／V2 receptor antagonist；②The group of rats with heart faulure received 5O g／I GS．③ A group of sham—oper— ated rats was given，which received Vl／V2 receptor antagonist．Parameters of hemodynamics and cardiac systolic，diastolic functions were recorded before and 10，2O，3O，4O．6O。9O 120 min after infusion in the three groups．RESULTS There WaS no change in SBP，DBP·M BP-LVSP and HR in rats with heart failure after infusion of AVP receptor antagonist．2O min after antagonist infu— sion．the LVEDP of the rats with heart failure decreased significantly．which 1asted to the end of the experiment．3O min after antagonist infusion,+dp／dt and -dp／dt inereaeaed obviously and reached the peak 4O min after the infusion．And at the same time L(1+ 2)，L(3+ 4)and Lo increased significantly．C0NCLUS10N After infusion of AVP V1／V2 receptor antagonist in rats with heart faulure cardiac systolic，diastolic function were improved，which has therapeutic eftect on congestive heart failure．

参考文献/References

[1]郑兴，章同华．王成海．等．充血性心力衰竭患者血浆糖氨酸加压素变化

[J]．临床心血管病杂志．1992，8(4)，2O1．

[2]孙刚．垂体后叶素和加压素对离体心肌的直接作用[J]．中国应用生理学杂志，1992，8(2)，15.

[3]俞可大．计算机用于心肌力学功能的测定研究[J]．生物力学，1989，4，62．

[4]Parmley ww．Neuroeadocrine change in heart failure and their clinical relevance[J]．Clin Cardiol．1995，18(8),440．

备注/Memo

备注/Memo:
收稿日期：1999-11-30.
更新日期/Last Update: 2001-01-25