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|本期目录/Table of Contents|

新型颈动脉再狭窄兔模型的建立(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第4期
页码:
279-281
栏目:
论著
出版日期:
2001-07-01

文章信息/Info

Title:
Establishment of a new restenosis model in carotid artery of rabbit
作者:
汝磊生;  贾国良;  李　飞;  李　妍;  张荣庆;  李　伟;  徐　凯
第四军医大学西京医院心内科, 陕西西安710032
Author(s):
RU Lei-sheng ;  JIA Guo-liang ; LI Fei; LI Yan;  ZHANG Rong-qing ; LI Wei;  Xu Kai
Department of Cardiology , Xijing Hospital, Fourth Military Medical University, Xi’an Shaanxi 710032, China
关键词:
颈总动脉;  兔;  再狭窄;  模型
Keywords:
carotid artery;  rabbit ;  restenosis;  model
分类号:
R33-33
DOI:
-
文献标识码:
A
摘要:
目的 为了解再狭窄发生机制, 进行再狭窄预防研究建立新西兰兔动物模型。方法 采用直流电刺激的方法刺激兔颈总动脉外膜, 在初步产生动脉纤维斑块的基础上, 给予球囊扩张。结果 通过血管造影及组织形态学观察, 证实兔颈总动脉发生了动脉再狭窄病理改变。模型组血管腔内面积明显缩小(P<0. 01) , 血管内膜增厚(P<0. 01)。结论 采用封闭群动物新西兰兔建立的颈总动脉狭窄模型具有模拟性好、死亡率低、实用性强和成功率高等优点。
Abstract:
AIM To establish an animal model to study the mechanism of restenosis for preventing and treating restenosis. METHODS After induction of an intimal plaque in the right carotid artery by electrical stimulation, the rabbits underwent balloon angioplasty. RESULTS By observation of the macrophages and angiography,we confirmed that the right carotid artery had the pathological changes of restenosis in the intervention group. CONCLUSION For its adventages such as low mortality, high practicability and good reproduce, the model is an ideal model for study of the mechanism and the prevention of restenosis.

参考文献/References

[1] 陈金明, 吴宗贵. 冠状动脉再狭窄的理论与实践[M] 上海: 第二军医大学出版社, 1999. 24-29.

[2] Barry WL , Wiegman PJ , Gimple LW , et al. A new single-injury model of balloon angioplasty in cholesterol-fed rabbits:beneficial effect of hirudin and comparison with double-injury model[J]. Lab Invest, 1997, 77(1): 109-116.

[3] Kakuta T, Usui M , Coats WD, et al. Arterial remodeling at the reference site after angioplasty in the atherosclerotic rabbit model[J]. Arterioscler Thromb Vasc Biol, 1998, 18(1): 47-51.

[4] Kipshidze N , Sahota H, Komorowski R, et al.Photo remodeling of arterial wall reduces restenosis after balloon angioplasty in an atherosclerotic rabbit model [J]. J Am Coll Cardiol, 1998, 31(5): 1152-1157.

[5] Yasuda S, Noguchi T, Gohda M , et al. Single low-dose administration of human recombinant hepatocyte growth factor attenuates intimal hyperplasia in a balloon-injured rabbit iliac artery model[J]. Circulation, 2000, 30, 101(21): 2546-2549.

[6] 施新猷. 医用实验动物学[M]. 西安: 陕西科学技术出版社,1989. 237-238.

备注/Memo

备注/Memo:
收稿日期：2001-03-13.
更新日期/Last Update: 2001-07-01