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|本期目录/Table of Contents|

充血性心力衰竭QT离散度变化及美托洛尔对其影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第4期
页码:
313-314
栏目:
论著
出版日期:
2001-07-01

文章信息/Info

Title:
QT interval dispersion in congestive heart failure and the effect of metoprolol on QTd
作者:
朱平先
深圳市龙岗中心医院，广东深圳518116
Author(s):
ZHU Ping-xian
Longgang Central Hospital of Shenzhen，Shenzhen Guangdong 518116，China
关键词:
心力衰竭; 充血性; QT离散度; 美托洛尔; 心律失常; 室性; 猝死
Keywords:
heart failure; congestive; QT interval dispersion; metoprolol; arrhythmia; ventricularl sudden death
分类号:
R541.6；F541.7；R540.41
DOI:
-
文献标识码:
A
摘要:
目的 测定充血性心力衰竭(CHF)患者的QT离散度(QTd)及美托洛尔对QTd的影响.方法 l10例CHF患者和50例健康人同时作QTd测量，CHF患者中38例进行美托洛尔治疗．与未使用美托洛尔的78例作比较。结果 CHF患者的QTd明显高于健康人(P<0．O1)；QTd与心功能受损的程度呈正相关；CHF伴室性心律失常者QTd大于不伴室性心律失常者(P<0．05)；予美托洛尔治疗后CHF患者QTd明显缩短(P<0．05)。 结论 CHF患者QTd明显增大。共托洛尔可使QTd缩小，对防治严重心律失常和猝死有重要意义。
Abstract:
AIM To detect the changes of QT interval dispersion(QTd) in congestive heart failure (CHF)and the effects of metoprolol on QTd．METHODS The QTd was measured in ll0 patients with CHF and 50 healthy peoples．38 patients with CHF were recruited at random from ll0 cases and treated by metoprolol，78 cases serving as controls．The QTd was measured before and four weeks after the treatment．RESULTS The QTd in CHF was significantly prolonged as compared with that of healthy people(P<0．01)．The QTd WRS positively correlated with the NYHA class of cardiac function．The QTd in CHF patients with ventricular arrhythmias obviously increased as compared with that in CHF patients without ventricular arrhythmias(P< 0．O5)．In the ptients treated with metoprolol，QTd significantly reduced(P< 0．05)．C0NCLUSI0N The QTd was prolonged in CHF．The QTd in CHF with ventrlcular arrhythmia obviously increased．Metoprolol could diminish the QTd in CHF，which is beneficial to the prevention of malignant ventricular arrhythmia and sudden death．

参考文献/References

[1]Sharpe N，Doughty R Epidemiology of heart failure and ventficular dysfunction[J]．Lancet，1998．352(Supp1):3-7.

[2]Cnvrie MR, Mosterd A ,Wood DA，et al．The epidemidogy of heart failure[J]．Eur Heart J，1997，18:208-225．

[3] Pye M，Quinn AC，Cabbe SM．QT interval dispersion:A non-invotive marker of susceptibility to arrhythmia in patients with sustained ventricular arrhythmias?[J]．Br Heart J，1994，71:5l1-5l4．

[4]Kautzner J，Malik M. QT interval dispersion and its clinical utility[J].Pacing Clin Electrophysiol,1997，62：211-216．

[5] Massie BM．15 year of heart-failure trial: what have we learned [J].Lancet,l998，352(Suppl)：29-33．

[6] Ryden L，Remme WJ，Treatment of congestive heart failure:Has the time come for decreased complexity?[J]．Eur Heart J,1999,20：398-399．

[7]Higham PD，Hilton CJ,Altcheson JD，et al.Does QT dispersion reflect dispersion of ventricular recovery?[J]. Circulation, 1992,86(suppl):392-394．

备注/Memo

备注/Memo:
收稿日期：2000-05-22.
更新日期/Last Update: 2001-07-01