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风湿性心脏病心房纤颤和窦性心律患者心房肌细胞外向钾电流的比较(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第6期
页码:
433-434,439
栏目:
论著
出版日期:
2001-11-01

文章信息/Info

Title:
Comparative study on outward potassium current in patients with atrial fibrillation and sinus rhythm of rheumatic heart disease
作者:
周更须1 梁延春2 张荣庆3 蔡振杰1 贾国良3 郭 群4 张作明4
第四军医大学: 1. 西京医院心脏外科, 3. 西京医院心脏内科, 4. 空军医学系临床医学教研室, 陕西西安710032, 2. 沈阳军区总医院心脏内科, 辽宁沈阳110015
Author(s):
ZHOU Geng-xu1 LIANG Yan-chun2 ZHANG Rong-qing3 CAI Zhen-jie1 JIA Guo-liang3 GUO Qun4 ZHANG Zuo-ming4
1. Department of Cardiovascular Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an Shaanxi 710032, China
关键词:
心房纤颤 外向钾电流 心房电重构
Keywords:
atrial fibrillation outward potassium current atrial electrical remodeling
分类号:
R541. 2; R541. 75 
DOI:
-
文献标识码:
A
摘要:
目的 探讨外向钾(K+) 电流的变化在风湿性心脏病(RHD) 心房纤颤(AF) 心房电重构(AER) 中的作用。方法 采用酶解法获得人心房肌单个细胞, 利用膜片钳技术的全细胞记录法, 记录RHD AF 和窦性心律患者心房肌细胞外向性K+ 电流的两个主要组分瞬时外向钾电流( Ito ) 和持续外向钾电流( IKSUS)。结果 AF 患者心房肌细胞Ito和IKSUS在不同除极电压下均较窦性心律患者明显减小(P<0. 01)。结论 外向电流减小是复极延缓的因素, 外向钾电流的减小可能在慢性AF 引起AER 中不起主要作用。
Abstract:
A IM To investigate the role of the change in the outward potassium current in the atrial electrical remodeling (AER ) caused by atrial fibrillation in rheumatic heart disease. METHODS Single atrialmyocytes were got by enzymatic digestion, and whole cell mode of patch clamp technique was used to measure the densities of transient outward potassium ( Ito ) current and sustained outward potassium current ( IKSUS). RESULTS The densities of Ito and IKSUS in AF patients were significantly lower than those of the patients with sinus rhythm. CONCLUTION The decrease in outward potassium current is not the main mechanism of AER.

参考文献/References

[1]Wijffels MC, Kirchhof CJ , Dorland R, et al. Atrial fibrillation begets atrial fibrillation: a study in awake chronicaly instrumented goats [J]. Circulation, 1995, 92 (7) : 1954.

[2] 梁延春, 张荣庆, 周更须, 等. 一种快速实用的人心房肌细胞分离方法[J]. 心脏杂志, 2000, 25 (4) : 135.

[3] Yue L , Feng J , Gaspo R, et al. Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation[J].Circ Res, 1997, 81 (4) : 512.

备注/Memo

备注/Memo:
收稿日期:2000-12-28.
更新日期/Last Update: 2001-11-01