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无创血管内皮舒张功能与冠心病的关联性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第6期
页码:
446-447
栏目:
论著
出版日期:
2001-11-01

文章信息/Info

Title:
The relation between non- invasive detectin of endothel ium-dependent relaxing function and coronary heart disease
作者:
刘建平;  梁春香;  牟楠楠;  曲　歌;  尤乃祯
济南军区总医院心内科, 山东济南250031
Author(s):
LIU Jian-ping ; LIANG Chun-xiang ; MU Nan-nan; QU Ge;  YOU Nai-zhen
Cardiovascular Department, General Hospital of Ji’nan Military Command, Ji’nan, Shandong 250031, China
关键词:
冠状动脉疾病;  冠状动脉造影;  高分辨超声;  肱动脉;  内皮依赖性血管舒张功能
Keywords:
coronary disease;  coronary angiography;  high-resolution ultrasound;  brachial arteries; endothelium-dependent relaxing function
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨无创血管内皮舒张功能与冠心病的关联性。方法 经冠状动脉造影证实的冠心病患者30 例, 分为冠心病I 组17 例, 冠心病II组13 例。对照组20 例, 为健康查体者。肱动脉内皮依赖性舒张功能测定用无创高分辨超声法。结果 ① 3 组基础血管内径无差异。②反应性充血后肱动脉内径变化百分数, 冠心病I 组(11±4)%、冠心病II 组(6±2)% , 对照组(16±5)% , 3 组间差异显著(I vs II P < 0. 01; I, II vs 对照组均P < 0. 01)。③含化硝酸甘油后肱动脉内径变化百分数, 冠心病I 组(17±5)%、冠心病? 组(14±3)% , 对照组(25±7)% , I 组, II 组与对照组比较差异显著(均P < 0. 01) ; I 组与II 组间无显著差异。结论 用高分辨超声测定的肱动脉内皮依赖性舒张功能与冠心病患者冠状动脉粥样硬化程度有关联。
Abstract:
AIM To explorate the relation between endothelium-dependent relaxing function and coronary heart disease(CHD). METHODS Thirty cases with CHD confirmed by coronary angiography were classified as two groups, CHD Grpup I with 17 cases and CHD Group II with 13 cases. 20 healthy individuals served as the control group. Brachial endothelium-dependent relaxing function was detected by high-resolution ultrasound. RESULTS ①No difference was detected in the basic diameters of the brachial arteries of the three groups. ②Flow -mediated dilatation of the brachial arteries in the three groups were (11±4)% , (6±2)% , (16±5)% respectively.There were significant differences among three groups (I vs II P < 0. 01, I , II vs the control group both P < 0. 01). ③The vasodilatadion responses to nitroglycerin in the CHD groups [I( 17±5)% , II (14±3)% ] was significantly different comparied with that of the control group (25±7)% (both P < 0. 01). But there was no significant change between CHD Group I and CHD Group II. CONCLUSION There exists a relation between endothlium-dependen trelaxing function detected by high-resolution ultrasound and the severity of AS in patients with CHD.

参考文献/References

[1] Celermajer DS, Sorensen KE, Gooch VM , et al. Non-invasive ditection of endothelial dysfunction in children and adults at risk of atherosclerosis[J]. Lencet, 1992, 340: 1111.

[2] 张湘瑜, 赵永平. 内皮功能失调与动脉粥样硬化[J]. 心血管病学进展, 1999, 20 (4) : 241.

[3] 周少春, 郑振声. 血管内皮功能障碍的早期检测及对策[J]. 岭南心血管病杂志, 1998, 4 (1) : 62.

[4] 李　江, 赵水平, 李向平. 辛伐他汀降脂治疗对血管内皮依赖性舒张功能的影响[J]. 中华心血管病杂志, 1998, 26 (4) : 278.

备注/Memo

备注/Memo:
收稿日期：2000-06-16.
更新日期/Last Update: 2001-11-01