我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

国产盐酸艾司洛尔的电生理学特性的研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2001年第6期
页码:
456-458
栏目:
论著
出版日期:
2001-11-01

文章信息/Info

Title:
Electrophysiologic study of the effects of esmolol hydrochloride produced by our country
作者:
袁　红1;  陶谦民2;  陈　瑶2
1. 余杭市第一人民医院心内科, 浙江余杭311100; 2. 浙江大学医学院附属第一医院心内科
Author(s):
YUAN Hong1;  TAO Qian-min2;  CHEN Yao2
1. Department of Cardiology, First Hospital of Yuhang, Yuhang Zhejiang 311100, China
关键词:
盐酸艾司洛尔;  电生理学;  心脏导管插入术
Keywords:
Esmolol;  hydrocloride;  electrophysiology;  cardiac catheterization
分类号:
R331.4; R972.2　
DOI:
-
文献标识码:
A
摘要:
目的 观察国产盐酸艾司洛尔对中国人的电生理学效应, 以评价其临床应用前景。方法 对20 例行心内电生理检查的患者分别于静注艾司洛尔前及注射过程中测定各项心脏电生理指标, 包括窦房结、心房、房室结、心室以及希2浦系功能, 同时, 观察血压、心率与心电图各项参数的变化。结果 用药时窦房结恢复时间、心房有效不应期、 房室结有效不应期、房室结前传文氏点、A-H 间期明显延长, 而窦房结传导时间、P2A 间期、H2V 间期、心室有效不应期以及心电图及各项参数无明显改变。对正常人SBP 无影响, 但可降低DBP,MBP, HR 及心率、血压乘积(RPP) , 从而降低心肌耗氧量, 而在停药后20 min 内HR,BP, RPP 即基本恢复至基础状态。结论 国产艾司洛尔主要作用于窦房结、心房与房室结, 而对希-浦系和心室功能无影响, 能迅速起效且在停药时间内使临床作用基本消失, 易根据临床状况的变化及时调整剂量, 提示其为急症情况下一种较为安全有效的理想药物。
Abstract:
AIM To investigate the electrophysiologic characteristics and clinical applications of esmolol produced in our country. METHODS Twenty patients underwent diagnostic electrophysiologic studies before and during B-blockade induced with esmolol. An initial loading dose of 500Lg.kg- 1.min- 1 was infused for 5 min and followed by a maintainance infusion of 250 Lg.kg- 1.min- 1 that was continued until the completion of the electrophysiologic measurements. The measurements were in itiated at 5 m in after the termination of the infusion. The side effects were observed simultaneously. RESULTS Esmolol significantly prolonged the sinus node recovery time, atrial and atrioventricular nodal effective refractory periods, the atrioventricular Wenckebach cycle length and A-H interval. But it produced a significantly reduction in heart rate (HR) , diastolic and mean blood pressure and rate-pressure product. It did not influence the sinoatrial conduction time, P-A and H-V interval, ventricular effective refractory period, systolic blood pressure and electrocardiographic parameters (P > 0. 05). CONCLUSION The electrophysiologic characteristics of esmolol produced in our country were similar to those reported abroad. Its major effects were on sinus node and AV node functions. Esmolol also showed no direct effects on HisPurkinje or ventricular function. Esmolol decreased the HR and the myocardial oxygen demand.Esmolol, because of its ultrashort duration of action, could be safe and efficient in emergency treatments.

参考文献/References

[1] Gorczynski RJ. Basic pharmacology of esmolol[J]. Am J Cardiol, 1985, 56: 3F- 13F.

[2] Greenspan AM , Spielman SR, Horowiz LB, et al. Electrophysiology of esmolol[J]. Am J Cardiol, 1985, 56: 19F- 26F.

[3] Donald R. Miller Bolus administration of esmolol for controlling the haemodynamic response to tracheal intubation: the Canadian Multicentre Trial[J]. Can J Anaesth, 1991, 38 (7) : 849- 858.

[4] Sung RJ , Blanski L , Kirshenbaum J , et al. Clinical experience with esmolol, a short-acting beta-adrenergic blocker in cardiac arrhythmias and myocardial ischemia [J]. 1986, 26 (Suppl. A ) :A15- A26.

[5] 游　凯, 严晓伟, 任洪智, 等. 静脉艾司洛尔治疗快速室上性心律失常临床疗效及安全性评价[J]. 中华心血管病杂志, 1996,24 (6) : 404- 407.

[6] Lange R, Kloner RA ,Braunwald E. Enhancement of functional recovery of“stunned”, reperfused myocardium by a new ultrashort-acting beta blocker [J]. Jam Coll Cardiol, 1984, 3: 545.

备注/Memo

备注/Memo:
收稿日期：2000-08-02.
更新日期/Last Update: 2001-11-01