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自制经静脉心肌声学造影剂FCT-188 的初步应用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第1期
页码:
48-51
栏目:
论著
出版日期:
2002-01-01

文章信息/Info

Title:
Preliminary application study of intravenous myocardial echocontrast agent (FCT-188)
作者:
钱学贤;  唐晓明;  吴志坚;  刘　磊;  靳亚菲;  彭　榕
第一军医大学第二附属医院心内科, 广东 广州 510282
Author(s):
QIAN Xue-xian;  TANG Xiao-ming ;  WU Xhi-jian;  LIU Lei;  JIN Ya-fei;  PENG Rong
Department of cardiology, Zhu jiang hospital, First Military Medical University, Guangzhou,guangdong 510282, China
关键词:
心肌缺血/再灌注;  犬;  对比超声心动图;  人
Keywords:
myocardial ischemia/reperfusion;  canines;  myocardial echocardiography;  human
分类号:
R445
DOI:
-
文献标识码:
A
摘要:
目的 应用自制对比造影剂FCT-188 无创性评估犬心肌缺血?再灌注模型心肌危险面积(RA) 和梗死面积(IA) ; 观察经静脉注射后人心肌显像效果。方法 制作犬心肌缺血-再灌注模型, 经外周静脉注射FCT-188 (0.025ml·kg-1)。MCE 测量结果与大体标本测量结果进行比较。12 名志愿者接受了经浅静脉注射FCT-188 (0.5ml)。结果 ①结扎冠脉前, 静注FCT-188 后7只犬全部达到肉眼可分辨的心肌显影。结扎冠脉20min及4h后, 相应支配区出现肉眼可见的充盈缺损, 分别为RA和IA。MCE和病理测定结果呈良好相关。注射前后各项血流动力学指标无显著性改变。②静脉注射FCT2188 后12 人均产生了视觉可辨的心肌显影。受检查者在注射前后无任何不适, 心率和血压无明显改变。结论 FCT-188 可较准确地评估犬缺血心肌危险面积和梗死范围, 并可用于无创性评估人心肌灌注情况。。
Abstract:
AIM To evaluate the newly developed echo-contrast agent (FCT -188) in non-invasive assessment of risk areas (RA) and infarct areas (IA) in the can inemodel of ischemia/reperfusion and to evaluate the myocardial contrast imaging effects in humans. MWTHODS Preparation of can inemodel of ischemia/r eperfusion. MCE was performed after injection of FCT -188 (0. 025ml.kg- 1 ) into femoral vein. Twelve volunteers participated in the pre-clinical study. MCE was carried out before and after intravenous injection of 0. 5 ml of FCT -188. RESULTS Before occlusion of coronary artery, all of the 7 dogs were showed intense myocardial contract images.At 20 min and 4 h after occlusion, myocardial contract images with the perfusion space can be seen at the matched regions. Visual myocardial contrast images were obtained in all 12 volunteers. CONCLUSION FCT -188 can be used to assess risk areas and infarct area accurately.The results suggest that our newly developed echo-contrast agent, FCT -188, has the potential clinical implications for human MCE study.

参考文献/References

[1] 钱学贤. 冠状动脉粥样硬化性心脏病[A]. 钱学贤, 戴玉华, 孔华宇. 现代心血管病学[M]. 北京: 人民军医出版社, 1999. 857- 948.

[2] 唐晓明. 经静脉声学造影剂的制备和应用研究[D]. 广州: 第一

[3] Tang XM (唐晓明) , Qian XX (钱学贤) , Wu ZJ (吴志坚). et al.Non-invasive assessment of myocardial risk and infarct area incanine model of myocardial reperfusion by intravenous contrast echocardiography[J]. Chin Med J , 1999, 112 (1) : 9- 13.

[4] Grayburn PA , Erickson JM , Escobar J , et al. Peripheral intravenous myocardial contrast echocar-diography using a 2% dodecafluoropentane emulsion: Identification of myocardial risk area and infarct size in the canine model of ischemia [J]. J Am Coll Cardiol, 1995, 26: 1340- 1347.

[5] Porter TR, Li SP, Kricsfeld D, et al. Detection of myocardial perfusion in multiple echocardiographic windows with one intravenous injection of microbubbles using transient response second harmonic imaging[J]. J Am Coll Cardiol, 1997, 29: 791- 799.

[6] Kaul S, Senior R, Dittrich H, et al. Detection of coronary artery disease using myocardial contrast echocardiography:Comparison with 99m Tc-sestamibi single-photon emission computed tomography[J]. Circulation, 1997, 96: 785- 792.

备注/Memo

备注/Memo:
收稿日期：2000-12-28.
更新日期/Last Update: 2002-01-01