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|本期目录/Table of Contents|

犬顿抑心肌31P 磁共振波谱(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第1期
页码:
52-54
栏目:
论著
出版日期:
2002-01-01

文章信息/Info

Title:
31P MR spectroscopy in canine stunned myocardium
作者:
张卓立;  黄志兰;  赵海涛;  傅　莉;  张贵祥;  方　虹
第四军医大学西京医院放射科, 陕西 西安 710032
Author(s):
ZHANG Zhuo-li;  HUANG Zhi-lan;  ZHAO Hai-tao;  FU Li;  ZHANG Gui-xiang ;  FANG Hong
Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032, China
关键词:
顿抑心肌;  核磁共振波谱;  动物实验;  狗
Keywords:
stunned myocardium;  nuclear magnetic resonance;  laboratry;  dogs
分类号:
R445.2
DOI:
-
文献标识码:
A
摘要:
目的 观察顿抑心肌状态时心肌能量代谢变化规律。方法 8条健康犬以麻醉开胸结扎冠状动脉左前降支30min 后再灌注, 建立顿抑心肌动物模型, 定期用31P磁共振波谱(MRS) 检查高能磷酸盐代谢变化。结果 顿抑心肌再灌注后 h, Pcr/B-ATP 和pH 下降, Pi/Pcr 上升, Pcr/B-ATP 在再灌注4h 后可恢复至正常, 而Pi/Pcr上升持续到再灌注后3d, 12d 恢复正常水平。结论 ①31PMR 波谱方法能非侵入性测定心肌能量代谢; ②Pi/Pcr 变化较Pcr/B-ATP和pH的变化显著; ③顿抑心肌能量代谢逐渐恢复后, 持续性的心肌力学障碍与心肌细胞A TP 含量无明显关系。
Abstract:
AIM To define the dynamics of energy metabolism in stunned myocardium.METHODS Eight canine models of stunned myocardium were established by occluding LAD (30min) followed by reperfusion, and 31Pm agnetic resonance spectroscopy (MRS) of myocardium was performed. RESULTS In stunned myocardium , the Pcr/B-ATP and the pH decreased while Pi/Pcr increased 2h after the reperfusion. Pcr/B-ATP showed no abnormalities 4 h after the porfnsion but Pi/Pcr kept increasing for 3 d and did not return to normal until 12 d after the reperfusion. CONCLUSION ①31PMR was fit for non-invasive measurement of the metabolism in myocardium in clinical settings. ②31PMR studies revealed more impressive changes in Pi/Pcr than in Pcr/B-ATP and pH in the presence of stunned myocardium. ③The energy metabolism of myocardial cells returned to normal over time following reperfusion of the stunned myocardium.No definite relationship could be defined between the persistent myocardial mechanical abnormalities and ATP contents of myocardial cells.

参考文献/References

[1] Bolli R. Myocardial stunning in man[J]. Circulation, 1992, 86:1671- 1691.

[2] Braunwald E, Kloner RA. The stunned myocardium: prolonged, post-ischemic ventricular dysfunction [J].Circulation, 1982, 66: 1146- 1149.

[3] Taegtmaeyer H, Roberts F, Raine G. Energy metabolism inreperfused heart muscle: metabolism correlates to return of function[J]. Am Coll Cardiol, 1985, 6: 684- 690.

[4] Geshi E, Sordahl LA , Ito S, et al. Simultaneous evaluations of contractility and metabolism of stunned myocardium using 31Pmagnet resonance spectroscopy[J]. Jpn Heart J , 1998, 39 (6) :791- 807.

[5] Hashimoto K, Nishimura T, Imahashi KI, et al. Lumped constant for deoxyglucose in decreased myocardial glucose uptake is enhanced[J]. Am J Physiol, 1999, 276 (1 pt 2) : H129- 133.

[6] Kalil-Filho R, de Albuquerquer CP, Weiss RG, et al. Normal high energy phosphate ratios in " stunne" human myocardium[J]. J Am Coll cardiol, 1997, 30 (5) : 1228- 1232.

备注/Memo

备注/Memo:
收稿日期：2001-03-20.
更新日期/Last Update: 2002-01-01