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扩张性心肌病与心绞痛患者心肌营养素-1与脑尿钠肽的变化(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第2期
页码:
132-133
栏目:
临床研究
出版日期:
2002-03-01

文章信息/Info

Title:
The changes of the cardiotrophin 1 and brain natriuretic peptide in patients with angina and idiopathic dilated cardiomyopathy
作者:
宋浩明;  罗　明;  邓南伟
同济大学附属同济医院心内科, 上海 200065
Author(s):
SONG Hao-ming; LUO Ming ; DENG Nan-wei
Department of Cardiology, Tongji Hospital, Tongji University, Shanghai 200065, China
关键词:
心肌病;  心绞痛;  细胞因子;  心肌营养素-1;  脑尿钠肽
Keywords:
cardiomyopathy;  angina pectoris;  cytokine;  cardiotrophin;  brain natriuretic peptide
分类号:
R541.4;R542.2
DOI:
-
文献标识码:
A
摘要:
目的 比较扩张性心肌病(DCM)与稳定型(SA)、不稳定型心绞痛(UA)患者外周血心肌营养素-1与脑尿钠肽的水平.方法 选择DCM和SA,UA患者各30例,并选择30例匹配的正常人作为对照组,检测心肌营养素-1(CT-1)和脑尿钠肽(BNP).结果 3组患者CT-1较正常对照组均明显增高(P<0.01),且DCM,UA组较SA组也明显升高(P<0.05);DCM与UA组的BNP较正常组明显升高(P<0.01),而SA组无显著差异(P>0.05).DCM组与UA组的CT-1和BNP水平无显著差异(P>0.05).结论 CT-1在DCM与UA的病程发展中起到重要作用;对于不稳定型心绞痛,CT-1可能与BNP相关.
Abstract:
AIM This study was sought to compare plasma cardiotrophin-1 and brain natriuretic peptide in patients with stable,unstable angina and idiopathic dilated cardiomyopathy. METHODS The concentration of CT-1 and BNP were measured from peripheral venous plasma in 30 healthy control subjects and 90 adult cardiac patients (30 had idiopathic dilated cardiomyopathy,30 had stable angina,30 had unstable angina). Then these samples were compared. RESULTS Plasma levels of CT-1 were significantly elevated in patients than in age-matched control subjects(P < 0. 01). And CT-1 in DCM and UA patients were more significantly elevated than in SA patients (P < 0. 05). Plasma levels of BNP were significantly elevated in DCM and UA patients (P <0. 01) while there is no significantly elevated in SA patients (P > 0. 05). The lever of CT-1 and BNP were not significantly different between DCM and UA patients (P > 0. 05). CONCLUSION The CT-1 may play an important role in the pathogenesis of DCM and UA. There are maybe an relation between CT-1 and BNP in unstable angina.

参考文献/References

[1] 华　平, 葛忠良. 白介素-6 细胞因子家族新成员: 心肌营养素-1[J]. 生物化学与生物物理进展, 1998, 25 (4) : 295.

[2] Pan J , Fukuda K, Saito M , et al. Mechanical stretch activates the JAK/STAT pathway in rat cardiomyocytes[J]. Circ Res, 1999,84: 1127.

[3] Talwar S,Downie PF, Squire IB, et al. An immunoluminometric assay for cardiotrophin-1: a newly identified cytokine is present in normal human plasma and is increased in heart failure [J].Biochem Biophys Res Commun, 1999, 261: 567.

[4] Yandle TG, Richards AM , Gillbert A , et al. Assay of brain natriuretic peptide (BNP) in human plasma: evidence for high molecular weight BNP as a major plasma comonent in heart failure[J]. J clin Endocrinol Metab, 1993, 76: 832.

[5] 秦卫国, 武彩娥, 李惠玲, 等. 扩张性心肌病及冠心病血浆白细胞介素6 的研究[J]. 临床心血管病杂志, 1995, 11: 351.

备注/Memo

备注/Memo:
收稿日期：2001-04-02.
更新日期/Last Update: 2002-03-01