«上一篇/Previous Article|本期目录/Table of Contents|下一篇/Next Article»

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2002年第4期

页码:

290-291,295

栏目:

实验研究

出版日期:

2002-07-01

文章信息/Info

Title:

Effects of acetylcholine on atrial fibrillation by a single extrastimulus in dog

作者:

卢少平;  杜日映;  郑强荪

第四军医大学唐都医院心内科, 陕西 西安 710038

Author(s):

LU Shao-ping ; DU Ri-ying ;  ZHENG Qiang-sun

Department of Cardiology, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710038, China

关键词:

乙酰胆碱;  有效不应期;  心房易损性;  持续时间

Keywords:

acetylcholine;  effective refractory period;  atrial vulnerability;  duration

分类号:

R541.7

DOI:

-

文献标识码:

A

摘要:

目的 研究不同浓度乙酰胆碱(Ach) 对心房不同部位有效不应期(ERP) 的影响及ERP 的变异对心房易损性和房颤(AF) 持续时间的影响。结果 ①Ach 可引起心房各部位ERP 减小,Ach 浓度越高, ERP 越小, ERP 的变异(COVERP) 越大(P<0.05)。②随着Ach 浓度增加,AF 的诱发率增高和持续时间延长。不同部位刺激诱发AF 的持续时间无显著性差异。③心房的易损性与ERP 和CO ERP 明显相关(P<0.05) ; 但AF 的持续时间只与COVERP 明显相关(P<0.05) , 而与ERP 无明显相关性。结论 Ach 诱发AF 的机制与心房的ERP 变异有关, 心房易损性和 F 的持续时间也与心房的ERP 变异明显相关。

Abstract:

AIM To study the effects of different concentration of acetylcholine(Ach) on effective refactory period(ERP) of different sites of atrium and the effects of the heterogeneity of ERP caused by Ach on atrial vulnerability and atrial fibrillation(AF) duration.RESULTS ①Ach decreaded ERP of four atrial sites.As increasing the concentration of Ach,ERP of 4 sites became shorter but COVERP became bigger.②As increasing the concentration of Ach,the percent of AF induced by Ach and AF duration increasing.AF duration was no difference by pacing at 4 sites(P > 0. 05).③There was a significant correlation between atrial vulnerability with ERP and COVERP(P<0.05),AF duration only had a significant correlation with COVERP(P<0.05). CONCLUSION AF induced by Ach was correlation with the heterogeneity of ERP. Atrial vulnerability and AF duration also had significant correlation with COVERP.

参考文献/References

[1] Thomas SP, Ross DL. Induction of atrial fibrillation and flutter in dogs using methacholine[J].J Interv Cardiol Electrophysiol, 1999,3:301-305.

[2] Fareh S,Villemaire S,Nattel S.Importance of refractoriness heterogeneity in the enhanced vulnerability to atrial fibrillation induction caused by tachycardia-induced atrial electrical remodeling[J].Circulation,1998,98:2202-2209.

[3] Wang J, Liu L, Feng J,et al. Regional and functional factors determining induction and maintenance of atrial fibrillation in dogs[J].Am J Physiol, 1996, 273:H148-H158.

[4] Moe GK,Rheinboldt WC,Abildskov JA.A computer model of atrial fibrillation[J].Am heart J,1964,67:200-220.

备注/Memo

备注/Memo:

收稿日期：2001-10-24.

常用功能

更新日期/Last Update: 2002-07-01