我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

苯那普利防治腹主动脉缩窄大鼠心律失常的实验研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第4期
页码:
292-295
栏目:
实验研究
出版日期:
2002-07-01

文章信息/Info

Title:
Prevention of cardiac arrhythmias in abdominal aortic-constricted rats by benazepril
作者:
周依蒙1;  陈润芬1;  周兆年2;  王长谦1;  王彬尧1;  黄定九1
1.上海第二医科大学附属仁济医院心内科, 上海 200001; 2.中国科学院上海生理所
Author(s):
ZHOU Yi-meng1;  CHEN Run-fen1;  ZHOU Zhao-nian2; WANG Chang-qian1; WANG Bin-yao1; HUANG Ding-jiu1
1.Department of Cardiology, Renji Hospital Affiliated to Shanghai Second Medical University, Shanghai 20001, China; 2.Shanghai Physiological Institute of Chinese A cademy of Sciences
关键词:
苯那普利;  左室肥厚;  心律失常
Keywords:
Benazepril;  left vent ricular hypert rophy;  arrhythmia
分类号:
R541.7;R972.2
DOI:
-
文献标识码:
A
摘要:
目的 探讨压力超负荷型心肌肥厚、心肌纤维化与室速、室颤诱发之间的关系, 及观察血管紧张素转化酶抑制剂苯那普利可能的干预作用。方法 采用Langendo rff 离体灌流装置, 电刺激腹主动脉缩窄大鼠心脏诱发室速、室颤, 并采用免疫组化染色方法测定左室心内膜下心肌间质Ⅰ , Ⅲ 型胶原容积分数。结果 与单纯结扎组比较, 结扎后服用苯那普利的大鼠, 短阵猝发电刺激不易诱发室速、室颤和左室重量与体重之比及心肌间质Ⅰ 型胶原容积分数降低。结论 苯那普利可通过预防左室肥厚和心肌纤维化的发生, 维持心肌电稳定性, 增大在离体心脏诱发心律失常的难度。
Abstract:
AIM To investigate the relationship between pressure-overload cardiac hypertrophy, the extent of myocardial fibrosis and ventricular arrhythmias induced by electrical stimulation, and the effect of angiotensin converting enzyme inhibitor Benazepril treatment.MEHTODS The incidence of ventricular tachycardia and ventricular fibrillation of the adbominal aortic-constricted rats(corac-rats) hearts induced by electrical stimulation was recorded using the Langendorff aortic retrograde perfused apparatus. The amounts of subendocardial interstitial collagen typeⅠand typeⅢin the left ventricle (LV) were measured by immunohistochemistry.RESULTS The arrhythmias induced by trains of stimuli were less frequent,and the LV weight/body weight ratio,the amount of collagen typeⅠwre lower in coarc-rats receiving Benazepril treatment compared with the operated group without treatment. CONCLUSION Benazepril can, by preventing the process of LVH and myocardial fibrosis,decrease the propensity of the hearts of coarc-rats for developing severe arrhythmias.

参考文献/References

[1] Messerli FH,Ventura HO,Elizardi DJ,et al. Hypertension and sudden death: increased ventricular ectopics activity in left ventricular hypertrophy[J].Am J Med,1984,77:18-22.

[2] Pahor M,Gambassi G,Carbonin P. Antiarrhythmic effects of ACE inhibitors:a matter of faith or reality? [J].Cardiovasc Res,1994,28:173-182.

[3] Assayag P,Carre F,Chevalier B,et al. Compensated cardiac hypertrophy: arrhythmogenecity and the new myocardial phenotype[J].Cardiovasc Res,1997,34:439-444.

[4] Dalton GR, Jones JV, Evans S,et al. Wall stress-induced arrhythmias in the working rat heart as LVH regrss during captopril treatment[J].Cardiovasc Res,1997,33:561-572.

[5] Chevalier B,Hendes D,Heyme S,et al. Trandolapril decreases prevalance of ventricular ectopic activity in middle-aged SHR [J].Circulation,1995,92:1949-1953.

[6] Rials S,Wu Y,Pauletto FJ,et al. Effect of an intravenous ACE inhibitor on the electrophysiologic features of normal and hypertrophied feline ventricles[J].Am Heart J,1996,132:989 -994.

[7] Flapan AD,Nolan J,Neilson JM. Effect of captopril on cardial parasympathetic activity in chronic cardiac failure secondary to coronary artery disease[J].Am J Cardiol,1992,69:532-535.

[8] Swynghedauw B. Molecular cardiology for the cardiologist[M].Boston: Kluwer Academic Press, 1995,275.

备注/Memo

备注/Memo:
收稿日期：2001-01-17.
更新日期/Last Update: 2002-07-01