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|本期目录/Table of Contents|

微温体外循环对von Willebrand因子及血栓调节蛋白的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第4期
页码:
312-314
栏目:
临床研究
出版日期:
2002-07-01

文章信息/Info

Title:
Effect of tepid temperature cardiopulmonary bypass on von Willbrand factor and thrombomodulin
作者:
向道康1;  孙宗全2;  赵长全3;  李正伦1;  阎兴治1;  舒义竹1
1.贵州省人民医院心外科,贵州贵阳550000;2.同济医科大学附属协和医院心外科;3.唐山市工人医院心外科
Author(s):
XIANG Dao-kang1;  SUN Zong-quan2;  ZHAO Chang-quan3;  LI Zheng-lun1;  YAN Xing-zhi1;  SHU Yi-zhu1
1. Department of Cardiovascular Surgery, Peoples′Hosptal of Guizhou Province, Guiyang,Guizhou 550000,China
关键词:
体外循环; 微温; von Willbrand因子; 血栓调节蛋白
Keywords:
cardiopulmonary bypass; tepid temperature; von Willebrand factor; thrombomodulin
分类号:
R654.1
DOI:
-
文献标识码:
A
摘要:
目的 观察微温体外循环对心内直视手术患者围术期von Willebrand因子(vWF)和血栓调节蛋白(TM)的影响。方法 36例风心病瓣膜置换患者随机分为实验组(鼻咽温32~34℃)和对照组(鼻咽温27~30℃),动态监测围术期血浆vWF及TM水平变化,并记录输血量及术后引流量。结果 实验组血浆vWF及TM水平在术中及术后24 h均低于对照组(P<0.05,P<0.01),且输血量及术后引流量也明显低于对照组(P<0.01)。结论 微温可减轻体外循环对血管内皮细胞的激活或损伤,有利于术后止血。
Abstract:
AIM To observe the effect of tepid temperature cardiopulmonary bypass(CPB) on the plasmatic von willibrand factor (vWF) and thrombomodulin (TM).METHODS Thirty-six cases were randomly divided into Group A (nasopharygeal temperature 32~34℃) and Group C(control group, nasopharygeal temperature 27~30℃). Changes in the parameters of plasmatic vWF and TM were measured at various time points during the whole period.RESULTS The plasmatic vWF and TM in Group A were significantly less than those in Group C during and 24 h after the operation(P<0.05 orP<0.01). Besides, allogeneic blood transfusions and the postoperation 24 h chest tube drainage were significantly less than those in Group C(P<0.01).CONCLUSION The tepid temperature CPB reduced postoperative blood loss and preserved endothelial cells.

参考文献/References

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[2]王振义,李家增,阮长耿.血栓与止血基础理论与临床[M].第2 版.上海:上海科学技术出版社,1996.8.

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[4] Edward MB Jr,Edward DV,Bruce DS,et al. Endothelial cell injury in cardiovascular surgery:The procoagulant response[J]. Ann Thorac Surg,1996,62(6):1549.

[ 5 ] Dittman WA, Majerus PW. Structure and function of thrombomodulin:a natural anticoagulant[J].Blood,1990,75: 329-336.

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备注/Memo

备注/Memo:
收稿日期：2001-04-16.
更新日期/Last Update: 2002-07-01