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抗纤维化治疗对慢性心力衰竭患者血清纤维化指标的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第4期
页码:
316-317
栏目:
临床研究
出版日期:
2002-07-01

文章信息/Info

Title:
Changes and significance of serum fibrotic markers in congestive heart falure
作者:
申源生; 侯文振; 马伟东; 吕汉文
惠州市中心人民医院心内科,广东惠州516001
Author(s):
SHEN Yuan-sheng; HOU Wen-zhen; MA Wei-dong; LU。Han-wen
Huizhou Central Hospital,Huizhou, Guangdong 516001,China
关键词:
心力衰竭; 慢性; 心肌纤维; 抗纤维化治疗
Keywords:
congestive heart failure; myocardial fibrosis; antifibrosis therapy
分类号:
R541.61
DOI:
-
文献标识码:
A
摘要:
目的 探讨抗纤维治疗对不同程度的慢性心力衰竭(CHF)患者的血清纤维化标志物:Ⅲ型前胶原(PCⅢ)、透明质酸(HA)和层粘蛋白(LN)的影响。方法 用放免法测定41例CHF患者血清PCⅢ,HA,LN的含量,比较不同程度CHF患者之间的差异,同时行抗纤维化治疗6~8周,检测治疗前后变化。结果 心功能Ⅲ,Ⅳ级患者的血清PCⅢ,HA,LN水平显著高于心功能Ⅱ级的患者(P<0.01);经抗纤维化治疗,血清PCⅢ,HA,LN水平显著下降(P<0.01),心功能明显改善。结论 血清PCⅢ,HA,LN参与了CHF的心肌纤维化;心肌纤维化随CHF的严重程度而加重;抗纤维化治疗,能减缓CHF患者的心肌纤维化。
Abstract:
AIM To assess the changes of serum procollagon type PCⅢ,hyaluronic acid(HA) and laminin (LN) in patients with congestive heart failure(CHF) and to investigate the effect of antifibrosis therapy on the above mentioned three serum fibrotic markers.METHODS Above mentioned three serum fibrotic markers were measured by specific radioimmunoassay and compared for the difference in 41 patients with varied degrees of CHF. All the patients with 2~3 scale of heart function were treated by antifibrosis. After 6~8 weeks therapy,all of the serum fibrotic markers were measured again.RESULTS The levels of PCⅢ,HA and LN with 3~4 scale heart function were significantly higher than those with 2 scale heart function (P<0.05,P<0.01). After the antifibrosis therapy,the levels of serum PCⅢ,HA and LN significantly dropped(P< 0.01).CONCLUSION Serum PCⅢ,HA and LN might be involved myocardial fibrosis of CHF. As CHF progressed,the myocardial fibrosis became more servere. Antifibrosis therapy could improve the prognosis of the patients with CHF.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2001-06-18.
更新日期/Last Update: 2002-07-01