我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

血管钠肽抑制心肌增殖与机制的研究(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2002年第5期
页码:
374-376
栏目:
基础研究
出版日期:
2002-09-01

文章信息/Info

Title:
The effects and mechanism of VNP attenuates myocardial proliferation
作者:
朱妙章; 吕顺艳; 于 军; 郭海涛; 董明清; 高 瞻; 魏启明
第四军医大学生理学教研室,陕西西安710032
Author(s):
ZHU Miao-zhang; LU。Shun-yan; YU Jun; GUO Hai-tao; DONG Ming-qing; GAO Zhan; WEI Qi-ming
Department of Physiology,Fourth Military Medical University,Xi' an,Shaanxi 710032
关键词:
血管钠肽; 增殖; 抑制; 机制
Keywords:
vasonatrin peptide; proliferation; inhibition; mechanism
分类号:
Q593.3
DOI:
-
文献标识码:
A
摘要:
应用NE、低氧或佛波酯(PMA)等方法刺激心肌细胞和心成纤维细胞的增殖,实验证明血管钠肽对增殖有抑制作用,它通过升高细胞内cGMP和降低细胞内Ca2+浓度等发挥作用,对肺动脉平滑肌细胞的增殖也有抑制作用,表明VNP对心肌细胞、心成纤维细胞和肺动脉平滑肌细胞有负调控作用,对心肌肥大和低氧性肺动脉高压有预防和治疗作用。
Abstract:
The proliferation of cardiac myocytes and cardiac fibroblasts induced by norepinephrine or hypoxia or phorbol 12-myristate 13-acetate(PMA),vasonatrin peptide(VNP) dose-dependently inhibit their growth-promating effects,which may be associated with the elevation of intracellular level of cGMP and decrease of intracellular calcium,VNP has also inhibitory effect on the proliferation of pulmonary artery smooth cells,results suggest that VNP has negative regulatory action on the gorwth of cardiac myocytes,cardiac fibroblasts and vascular smooth muscle cells,VNP possess preventable and theapeutic effects on cardiac hypertrophy and hypoxic pulmonary hypertension.

参考文献/References

[1] 吴其复,余应年,卢建.新编病理生理学[M].北京:中国协和医科大学出版社,1999.

[2] Tamamori M, Ito H,Hiroe M,et al. Stimulation of collagen synthesis in rat cardiac fibroblasts by exposure to hypoxic culture conditions and suppression of the effect by natriuretic peptides[J].Cell Biol Int,1997,21(3):175-180.

[3] 吕顺艳,朱妙章,郭海涛,等.血管钠肽对中度低氧诱导的心肌细胞蛋白合成有抑制作用[J].生理学报,2002;54(1):7~11.

[4]吕顺艳,朱妙章,郭海涛,等.血管钠肽抑制低氧诱导的心肌成纤维细胞的增殖和胶原合成[J].第四军医大学学报,2002,23(10):884-886.

[5] 郭海涛,朱妙章,吕顺艳,等.血管钠肽抑制低氧刺激心成纤维细胞c-fos的表达[J].第四军医大学学报,2001,22(3):204-207.

[6] 于 军,董明清,吕顺艳,等.血管钠肽减弱去甲肾上腺素对心肌细胞生长的刺激作用[J].心功能杂志,1999,11(3):145-148.[7] 于 军,朱妙章,董明清,等. VNP减弱NE刺激的心肌细胞c-fos表达[J].中国应用生理学杂志,2000,16(2):100-103.

[8] Kagamu H,Suzuki T,Arakawa M,et al. Low oxgen enhance endothelin-1(ET-1) production and responsiveness to ET-1 in culture candiac myocytes[J].Biochem Biophys Res Commun,1994,202(3):1612-1618.

[9] 朱妙章.大学生理学[M].北京:高等教育出版社,2002.

[10] 董明清,朱妙章,于 军,等.钠尿肽抑制SD乳鼠心肌细胞增殖[J].第四军医大学学报,2000,21(4):443-446.

[11] Fujisaki H,Ito H,Hirata Y,et al. Natriuretic peptide inhibit angiotensinⅡ-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 genexpression[J].J Clin Invest, 1995,96(4):1059-1065.

[12] Hutchinson HG,Trinde PT,Cunanan DB,et al. Mechanism of natriuretic-peptide-induce growth inhibition of vascular smooth muscle cells[J]. Cardiovasc Res,1997,35(1):158-167.

[13] 郭海涛,朱妙章,吕顺艳,等.血管钠肽抑制低氧对大鼠心成纤维细胞内钙浓度升高的作用[J].生理学报,2001,53(4):286-290.

[14] 董明清,朱妙章,于 军,等.三种钠尿抑制动脉平滑肌细胞增殖效应的比较[J].生理学报,2000,52(3):252-254.

[15] 董明清,于 军,朱妙章,等.血管钠肽对大鼠肺动脉平滑肌增殖的影响[J].中国应用生理学杂志,2000,16(2):148,184.

备注/Memo

备注/Memo:
收稿日期：2002-04-06.基金项目:国家自然科学基金资助项目 (No.3 9970327)
更新日期/Last Update: 2002-09-01