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乙醇对兔心脏活动与氧自由基的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第1期
页码:
7-8,11
栏目:
实验研究
出版日期:
2003-01-01

文章信息/Info

Title:
The effect of ethanol on heart's activity and oxygen free radicals of the rabbit
作者:
赵善民; 黄丽娟; 黄俊杰; 何显教; 晋玲
右江民族医学院应用生理研究室,广西 百色53300
Author(s):
ZHAO Shan-min; HUANG Li-juan; HUANG Jun-jie; HE Xian-jiao; JIN Lin
Institute of applied physiology,Youjiang Medical College for Nationalities,Bose,Guangxi 533000,China
关键词:
醇; 乙; 内压; 左心室; 超氧化物歧化酶; 丙二醛; 量效关系; 兔
Keywords:
alcohol;  ethyl;  internal pressure;  left ventricle;  Superoxide dismutase; malondialdehyde; dose-effectrelationship; rabbit
分类号:
R331.31;R313
DOI:
-
文献标识码:
A
摘要:
目的:探讨不同量的乙醇对心脏活动和血浆中超氧化物歧化酶(SOD)活力和丙二醛(MDA)含量的影响。方法:分别按家兔每kg体质量累加0.2,0.5,1.0,1.5,2.0g的乙醇从静脉给予,然后分别测定在不同量的乙醇作用下在体左心室内压变化情况,同时测定当时血浆中SOD活力和MDA的含量,并比较分析它们之间的关系。结果:随着乙醇量的增加,左心室内压下降明显,但在0.2～0.5g/kg时无明显变化。达1.0g/kg以上时才明显降低(P<0.05或P<0.01)。SOD活力0.2～0.5g/kg时增加,达1.0g/kg以上时降低;MDA含量在0.2～0.5g/kg时降低,超过1.0g/kg以上时增加。结论:乙醇量大对心脏有抑制作用,同时体内氧自由基产生增多。
Abstract:
AIM: To investigate the effect of ethanol on heart's activity,SOD's(superoxide dismutase)activity in blood plasma and the amount of MDA(malondialdehyde)by using different doses of ethanol.METHODS:The change of internal pressure of left ventricle in vivo,SOD's activity in blood plasma and the amount of MDA were measured by intravenously injecting the ethanol with accumulative doses of 0.2,0.5,1.0,1.5,and 2.0g per kg body weight.RESULTS:With the increasing dose of ethanol,the internal pressure of left ventricle obviously reduced.But it showed no distinct changes within 0.2～0.5g/kg but showed an evident decrease above the dose of 1.0g/kg (P<0.05orP<0.01).SOD activity increased with in 0.2～0.5g/kg and decreased above 1.0g/kg.Oppositely,MDA amount decreased with in 0.2～0.5g/kg and increased above 1.0g/kg.CONCLUSION:The study indicated that body's reaction to ethanol was related with the dose.A finite dose of ethanol would benefit health while an exciting dose would inhibit heart's activity and the oxygen free radicals would increase.

参考文献/References

[1] Fuch CS, Stampfer MJ, Golditz GA, et al. Alcohol and mortality among women [J] . N Engl J Med, 1995, (19):1245-1248.

[2] Ian C, Harrison S, White E, et al. The effect of a range of alcohols on the contraction of guinea pig ventricular myocytes [J] . Eur J pharmacol, 1993, 248:213-216.

[3] 赵善民, 晋玲, 黄丽娟, 等. 不同浓度乙醇对蟾蜍血压和心率的影响 [J] . 生物学杂志, 1996, 71(3):16-18.

[4] 赵善民, 晋玲, 何显教, 等. 乙醇对家兔血压、心率和微血管的影响 [J] . 心脏杂志, 2000, 12(4):295-297.

[5] 周衍椒, 赵轶千, 王雨若. 生理学方法与技术 [M] . 北京:北京科学出版社, 1984. 46-54.

[6] Abdel-Rahman AA. Acute effects of ethanol on cardiac output and its derivatives in spontaneously hypertensive and normotensive rats[J].J Pharmacol Exp Ther,1994,271(8):64-650.

[7] Klatsky AL. Armstrong MA. Friedman GD. Alcohol and mortality [J] . Ann Intern Med, 1992, 117:464-469.

[8] 莫简. 医用自由基生物学导论 [M] . 北京:人民卫生出版社, 1989, 16:17

[9] 闵姜勇. 氧自由基与心血管[J] . 临床荟萃, 1992, 8:344-345

[10] 周君富, 杜雨红, 王也玲, 等. 滥用酒精与氧化剂和抗氧化酶的关系 [J] . 中华预防医学杂志, 1998, 23(5):303-305

[11] 王福伟, 张翼, 谷双振. 酒精对心脏的保护和危害作用 [J] . 河北医科大学学报, 1999, 20(6):367-377.

[12] 任骏, 刘远德. 酒精对心血管系统的双向调节作用 [J] . 心血管病学进展, 1998, 19(2):73-76.

备注/Memo

备注/Memo:
收稿日期：2001-12-12.
更新日期/Last Update: 2003-01-01