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高血压病患者血浆神经肽Y、神经降压素水平的变化及意义(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第2期
页码:
126-128
栏目:
临床研究
出版日期:
2003-03-01

文章信息/Info

Title:
Changes in plasma neuropeptide Y,neurotensin levels of patients with essential hypertension and their clinical singnificanc
作者:
刘润梅1; 夏云峰1; 陈素娟2; 翟红霞1; 佟万仁1
1.解放军第304医院干一科,北京100037;2.北京东亚免疫技术研究所,北京 100853
Author(s):
LIU Run-mei1; XIA Yun-feng1; CHEN Su-juan2; ZHAI Hong-xia1; TONG Wan-ren1
1.Department of Internal Medicine,304 Hospital of PLA,Bei jing 100037,China;2.Dong ya Immuno-technology Institute,Beijing100853,China
关键词:
高血压; 心脏功能; 肾功能; 神经肽Y; 神经降压素
Keywords:
hypertension; cardiac function; kidney function; neuropeptide Y; neurotensin
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的:观察高血压病患者血浆神经肽Y(NPY)、神经降压素(NT)水平的变化,探讨其在高血压发病机制中的 作用及其与高血压靶器官损害的关系。方法:用放射免疫分析法检测符合高血压病诊断标准的80例高血压病患者 血浆NPY,NT浓度,同时检查患者心、肾等靶器官功能。结果:①高血压病患者血浆NPY水平高于对照组(P<0. 05)、而NT水平明显低于对照组(P<0.01)。②高血压病Ⅰ,Ⅱ,Ⅲ期患者间血浆NPY,NT水平差异明显(P<0. 01),NPY水平逐渐升高,而NT水平逐渐下降。心功能Ⅰ,Ⅱ,Ⅲ级高血压病患者间NPY,NT水平差异明显(P< 0.01),随心功能恶化,NPY水平升高,而NT水平降低。伴有室间隔和(或)左室后壁肥厚组血浆NPY水平高于室 间隔和左室后壁正常组(P<0.01),而NT水平则肥厚组低于正常组(P<0.01)。肾功能Ccr≤49ml/min组血浆 NPY水平高于Ccr≥50ml/min组(P<0.01),二组间NT水平无明显差异(P>0.05)。③高血压病患者血浆NPY 与NT水平呈负相关(r=-0.45,P<0.01)。结论:NPY,NT参与了高血压病的发病过程,与高血压病患者心脏、肾 脏功能损害程度相关,观察血浆NPY与NT水平变化有助于判断高血压病患者的病情和预后。
Abstract:
AMI:To observe the changes of plasma neuropeptide Y(NPY)and neurotensin(NT) levels in patients with essential hypertension and to investigate the significance of NPY and NT in the pathogenesis of hypertension and the relationship between NPY and NT and the damage of target organ.METHODS:The plasma NPY and NTconcentrations of 80 patients with essential hypertension and 28 normal controls were determined by radioimmunoassay(RIA).RESULTS:The level of NPY in patients of hypertension was higher than that of the normal controls (P<0.05), and the level of NT was significantly lower than that of the normal controls (P<0.01).The NPY and NT levels in the three periods of hypertension(periodⅠ,Ⅱ,Ⅲ) and in the three group divided on cardiac function(degreeⅠ,Ⅱ,Ⅲ) were all significantly different (P<0.01).With the severity of hypertension and heart failure,the NPY level increased,and the NT level decreased. The NPY level of the group with left ventricle hypertrophy(LVH) was significantly higher than that of the group with out LVH(P<0.01), and the NT level of the LVH group was significantly lower than that of the group with out LVH (P<0.01).The NPY level of the patients whose endogenous creatinine clearance rate(Ccr )was≤49ml/min was higher than the that of the patients with Ccr≥ 50ml/min(P< 0.01). There was no significant difference in NT level between the two groups (P>0.05).The plasma NPY and NT levels of the patients with essential hypertension were negatively correlated(r=-0.45,P<0.01). CONCLUSION:NPY and NT may participate in the pathophysiological course of hypertension.They may play a role in the damage of target organ function of the patients with primary hypertension

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2002-1-9.
更新日期/Last Update: 2003-03-01