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冠脉内支架置入术对血清cTnT和D-dimer的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第2期
页码:
129-130,133
栏目:
临床研究
出版日期:
2003-03-01

文章信息/Info

Title:
Effects of coronary stenting on blood levels of troponin T and D-dimer
作者:
张清; 王长谦; 厉锦华; 王彬尧; 韩志华; 谢秀兰; 黄定九
上海第二医科大学附属仁济医院心内科,上海 200001
Author(s):
ZHANG Qing; WANG Chang-qian; LI Jin-hua; WANG Bin-yao; HAN Zhi-hua; XIE Xiu lan; HUANG Ding-jiu
Department of Cardiology,Ren ji Hospital Affiliated to Shang hai Second Medical University,Shang hai200001,China
关键词:
冠脉内支架置入术; 肌钙蛋白T; D-二聚体
Keywords:
coronary stenting; cardiac troponin T; D-dimer
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:比较冠脉内支架置入术(CS)对血清心脏型肌钙蛋白T(cardiactroponinT,cTnT)和D-二聚体(Ddimer) 的影响,以探讨其临床意义。方法:进行CS术的冠心病患者48例,同时选择一组同期进行冠状动脉造影术 (CAG)的冠心病患者作为对照(n=30)。分别于CS或CAG术前及术后第二天清晨采集空腹血进行血液cTnT及 D-dimer水平的测定。结果:CS的患者,CS术后血清D-dimer水平显著高于术前(分别为1.4±2.0mg/Lvs0.9± 1.0mg/L,P<0.01);而CS术后血清cTnT水平与术前比较无显著差异(分别为0.38±1.43ng/mlvs0.30±0.32 ng/ml,P>0.05)。CS术后有6例患者cTnT增高,其中5例发生在D-dimer增高的患者中(P<0.05)。CAG的患 者,造影后血清D-dimer及cTnT水平与造影前比较均无显著差异(分别为0.5±0.5mg/Lvs0.8±0.4mg/L,P >0.05及0.03±0.02ng/mlvs0.03±0.01ng/ml,P>0.05)。结论:cTnT为检测心肌损伤的敏感指标。CS术后 血清cTnT水平稍有增加,而血清D-dimer水平较术前显著增高。D-dimer增高者易并发cTnT的增加。
Abstract:
AIM:To examine the effects of coronary stenting(CS) on blood levels of cardiac troponin T(cTnT) and D dimer, and to evaluate their clinical significance.METHODS:Forty-eight patients who underwent coronary stenting were included in this study,and thirty patients who received coronary angiography during the same period were selected as the controls.Blood samples for measurement of cTn T and D-dimer were taken before the procedure and the following early morning after the procedure.RESULTS:In patients with coronary stenting,D-dimer levels after the procedure were significantly higher than those before the procedure (1.4±2.0mg/Lvs0.9± 1.0mg/L,P< 0.01), but the blood levels of cTn T after the procedure were not significantly higher than those before the procedure(0.38±1.43ng/mlvs0.30±0.32ng/ml,P>0.05). The blood levels of cTn T in six patients were higher after coronary stenting,five among whome were patients with increased Ddimer(P<0.05). In the control group, both Ddimer and cTn T levels afte coronary angiography were not significantly higher than those before the angiography(0.5±0.5mg/Lvs0.8±0.4mg/L,P>0.05and0.03±0.02ng/mlvs0.03±0.01ng/ml,P>0.05,respectively).CONCLUSION: c Tn T serum level was a sensitive marker for monitoring myocardial injury. The blood level of c Tn T had rarely elevated after CS,but Ddimer levels after CS were significantly higher than those before the procedure. The patienrs with increased D-dimer were prone to c Tn T elevation

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2002-9-9.
更新日期/Last Update: 2003-03-01