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血管紧张素Ⅱ-1型受体基因多态性与冠状动脉血管病变及支架内再狭窄的关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第4期
页码:
303-305
栏目:
实验研究
出版日期:
2003-07-01

文章信息/Info

Title:
The relationship between angiotensin Ⅱ type Ⅰ receptor gene polymorphism and coronary atherosclerosis and in-stent restenos
作者:
王晖; 杨志健; 马根山; 朱铁兵; 尹航; 王连生; 曹克将; 黄峻
南京医科大学第一附属医院心脏科,江苏 南京 210029
Author(s):
WANG Hui;  YANG Zhi-jian;  MA Gen-shan;  ZHU Tie-bing;  YING Hang;  WANG Lian-sheng;  CAO Ke-jiang;  HUANG Jun
Department of Cardiology, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210029, China
关键词:
血管紧张素Ⅱ-1型受体; 基因多态性; 动脉硬化; 再狭窄
Keywords:
angiotensinⅡ receptor typeⅠ;  polymorphism;  atherosclerosis;  restenosis
分类号:
R543.3
DOI:
-
文献标识码:
A
摘要:
目的:探讨血管紧张素Ⅱ-1型受体(AT1R)基因的A1166C多态性与冠状血管动脉硬化进程以及支架术后血管内膜增殖的相关性。方法:对106例接受冠状动脉血管造影(CAG)和支架术的患者,采用PCR进行A1166C多态性检测,并对其中60例患者于半年内行CAG随访,按CAG结果分为再狭窄组与无再狭窄组。判定血管动脉硬化进程及再狭窄与AT1RA1166C多态性的相关性。结果:106例患者中无AT1RCC基因型。AT1RAA和AC型患者术前参照血管直径及最小管腔直径均无差异,血管平均狭窄程度也无差异(P>0.05)。再狭窄组中AA,AC和CC基因型频率分别为0.941,0.059和0.000,而无再狭窄组分别为0.885,0.115和0.000,两组间无显著性差异(x2=0.617,P=0.432)。再狭窄组1166C等位基因频率为0.029,无再狭窄组为0.058,无显著性差异(x2=0.59,P=0.442)。结论:AT1RA1166C多态性与血管动脉硬化进程及支架术后内膜的增殖无相关性。
Abstract:
AIM: To investigate the relationship between the angiotensinⅡ typeⅠ receptor gene and coronary atherosclerosis, and its effectonin-stent restenosis. METHODS: In this study AT1R gene polymorphisms were investigated in 106 corpnary artery disease patients, among which 60 patients were again taken angiography in 6 months after stent placement. These polymorphisms were analysed by PCR and restriction fragment length polymorphism (RFLP). RESULTS: No AT1R CC genotype was detected in our study. The study shows there were nostatistically significant difference in reference diameter, minimal lumen diameter and the degree of mean segment diamter before PTCA between AT1RAA and AC groups. In restenosis group,the AT1R AA, AC and CC genetype frequenty were 0.941, 0.059 and 0.000, against 0.885, 0.115 and 0.000, respectively in nonrestenosis group (x2=0.617,P=0.432). The frequency of 1166 Callele was 0.029 in restenosis group against 0.058 in non-restenosis group (x2=0.59,P=0.442). CONCLUSION: The frequency of AT1R genotype and C1166 allele was neither associated with the progression of coronary atherosclerosis nor with the in-stent restenosis.

参考文献/References

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[2] Katsuya T, Koite G, Yee TW, et al. Association of angiotensiogen T235 variant with increased risk of coronary heart disease [J] . Lancet, 1995, 345:1600-1603.

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[4] VanGeel PP, Pinto YM, Voors AA, et al. AngiotensinⅡ typeⅠ receptor A1166C polymorphism is associated with an increased response to angiotensinⅡ in human arteries [J] . Hypertension, 2000, 35:717-721.

[5] Carluccio M, Soccio M, DeCaterina R, et al.Aspects of gene polymorphismsin cardiovascular diseases: the renin-angiogensin system [J] . Eur J Clin Invest, 2001, 31:1-14.

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备注/Memo

备注/Memo:
收稿日期：2002-04-19.
更新日期/Last Update: 2003-07-01