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|本期目录/Table of Contents|

可溶性P-选择素与急性冠状动脉综合征的关联性*(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第4期
页码:
326-327,330
栏目:
临床研究
出版日期:
2003-07-01

文章信息/Info

Title:
The relationship between serum soluble P-selectin levels and acute coronary syndrome
作者:
陈浩; 李源; 王晓明
第四军医大学西京医院老年病科,陕西 西安 710032
Author(s):
CHEN Hao;  LI Yuan;  WANG Xiao-ming
Department of Geriatrics, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China
关键词:
冠状动脉疾病; 急性冠脉综合征; P-选择素
Keywords:
coronary disease;  acute coronary syndrome;  P-selectin
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:观察急性冠状动脉综合征与血清中可溶性P-选择素的关联性。方法:采用ELISA法检测32例不稳定型心绞痛(UA)、47例急性心肌梗死(AMI)、30例稳定型心绞痛(SA)患者和40例健康者(对照组)血清可溶性P-选择素水平。结果:对照组和SA组分别为1321±121ng·L-1和1520±113ng·L-1,而UA组和AMI组可溶性P-选择素明显升高(分别为7645±950ng·L-1和4665±444ng·L-1,P<0.05)。结论:可溶性P-选择素与急性冠状动脉综合征有关联。
Abstract:
AIM: To investigate the relationship between serum soluble P-selectin levels and acute coronary syndrome. METHODS: The levels of serum soluble P-selectin were determined by enzyme-linked immunosorbent assay in 32 unstable angina (UA) cases, 47 acute myocardial infarction (AMI) cases, 30 stable angina (SA) cases and 40 healthy cases as control. RESULTS: Compared with the healthy control cases (1321±121ng·L-1) and SA cases (1520±113ng·L-1), the levels of soluble P-selectin increased significantly in the AMI cases and UA cases (7645±950ng·L-1 and 4665±444ng·L-1,P<0.05,respectively). CONCLUSION: The increased solubleP-selectin levels is related to the formation and progression of acute coronary syndrome.

参考文献/References

[1] Burns AR, Bowden RA, Abe Y, et al. P-selectin mediates neutrophil adhesion to endothelial cell borders [J] . Leukocyte Biol, 1999, 65:299-306.

[2] Miura T, Nelson DP, Schermerhorn ML, et al. Blockade of selectin-mediated leukocyte adhesion improves postischemic function in lamb hearts [J] . Ann Thorac Surg, 1996, 62:1295-1300.

[3] 仲任, 宋善俊. P-选择素和急性冠脉综合征 [J] . 国外医学·输血及血液分册, 2001, 24:295-297.

[4] Michelson AD, Barnard MR, Krueger LA, et al. Circulation monocyte-platelet aggregates area more sensitve marker of in vivo platelet activation than platelet surface P-selectin: studies inbaboons, human coronary intervention, and human acute myocardial infarction [J] . Circulation, 2001, 104:1533-1537.

[5] Xu DY, Zhao SP, Peng WP. The changes of plasma P-selectin in patients with coronary heart disease [J] . Chin J Cardiol, 1999, 27:439-439.

[6] 袁红, 杨明清. 选择素与心血管疾病 [J] . 心肺血管杂志, 2001, 20:189-190.

备注/Memo

备注/Memo:
收稿日期：2002-11-27.
更新日期/Last Update: 2003-07-01