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|本期目录/Table of Contents|

联合用药组方治疗原发性高血压远期疗效(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2003年第4期
页码:
328-330
栏目:
临床研究
出版日期:
2003-07-01

文章信息/Info

Title:
Comparison of long-term efficacy of two combination of prescriptions in treatment of essential hypertension
作者:
王静
内蒙古自治区医院,内蒙古呼和浩特 010017
Author(s):
WANG Jing
Inner Mongolia Hospital, Huhehaot, Nei Monggo l010017, China
关键词:
高血压; 原发性; 联合用药组方; 长期用药
Keywords:
hypertension;  essential;  prescription combinations;  long-termp rescription
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的:观察两个联合用药组方治疗原发性高血压的远期临床效果。方法:高血压患者106例,随机分成长期用药组和对照组各53例。长期用药组又随机分为甲、乙两组,其中甲组25例,服用组方1(双氢克尿噻和硝苯地平片各7.5mg),乙组28例,服用组方2(尼群地平片3mg,依那普利片1.5mg和吲哒帕胺片0.5mg),对照组患者自行或间断服药。结果:长期用药组与对照组相比能显著地降低高血压患者的收缩压和舒张压(P<0.01),甲组和乙组降压幅度无显著性差异(P>0.05),对心率均无显著性影响(P>0.05),副作用均较轻微。结论:两个联合用药组方治疗原发性高血压远期疗效稳定可靠,而且可明显减少心脑血管事件的发生率
Abstract:
AIM: To observe the long-term clinical efficacy of two combinations of pressriptions in treatment of essential hypertension. METHODS: 106 cases of essential hypertension patients were randomly divided into the long-term prescription and control groups, each 53 subjects. The long term prescription group was randomly divided into two groups, in which the first group (25 cases) intake combination 1 (Dihydrochlorothiazide 7.5mg, Nifedipine 7.5mg); these cond group (28 cases) intake combination 2 (Indapamide 0.5mg, Nitrendipine 3mg, Enalapril1. 5mg). The subjects in the control group interruptedly intake medicine without doctors' guidance. RESULTS: The systolic pressure and diastolic pressure drop dramatically compared with those of the control group members (P<0.01). Between the first and second groups, there is no striking difference in the range of the decline of blood pressure (P>0.05), and their cardiac rates are not affected (P>0.05); side effects of the medicine used by the two group subjects are slight. CONCLUSION: The long-term efficacy of two combinations of prescriptions are steady and reliable intreatment of essential hypertension and the incidence of the heart and brain artery events drop dramatically.

参考文献/References

[1] 心血管病流行学及人群防治汇报讨论会. 常规心血管病流行病学研究及人群防治工作1979～1985年规划 [J] . 中华心血管病杂志, 1979, 7:81.

[2] 刘国仗, 齐建华, 明广华. 大力开展高血压的人群防治是时代的主题 [J] . 中国慢性病预防与控制, 1996, 4(3):97.

[3] 中华心血管病杂志编委会心血管药物对策专题组.心血管药的临床试验评价方法的建议·Ⅱ·抗高血压药 [J] . 中华心血管病杂志, 1998, 26:7-9.

[4] Johnson GD. Selecting appropriate antihypertensive drug dosage [J] . Drugs, 1994, 47(4):567-575.

[5] Papademetrion V, Prisant LM, Neutel JM, et al. Efficacy of low dose combination of bisoprolol/hydrochlorothazide compared with amlodipine and enalapril in men and women with essential hypertension [J] . Am J Cardiol, 1998, 81:1363-1365.

[6] 陈淇. 现代心脏病治疗指南 [M] . 北京:科学出版社, 1993. 488-490.

备注/Memo

备注/Memo:
收稿日期：2002-03-07.
更新日期/Last Update: 2003-07-01