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《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:

2004年第1期

页码:

62-63,66

栏目:

临床研究

出版日期:

2004-01-01

文章信息/Info

Title:

Changes in hemorrheology and their correlation with the changes in oxidated lowdensity-lipoprotein in coronary heart disease patients

作者:

罗兰¹; 王为忠¹; 管文贤¹; 李秦¹; 秦清²; 王海风¹; 李孟斌¹; 季刚¹

第四军医大学西京医院:1.胃肠外科,2.检验科,陕西 西安 710032

Author(s):

LUO Lan¹; WANG Wei-zhong¹; GUAN Wen-xian¹; LI Qin¹; QIN Qing²; WANG Hai-feng¹; LI Meng-bin¹; JI Gang¹

1.Department of Gastrointestinal Surgery, 2.Department of Clinical Laboratories Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032,Chin

关键词:

冠状动脉疾病; 血液流变学; 氧化低密度脂蛋白; 脂质过氧化物; 超氧化歧化酶

Keywords:

coronary disease;  hemorreology;  oxidate low-density lipoprotein;  lipoperoxide;  superoxide dismutase

分类号:

R541.4

DOI:

-

文献标识码:

A

摘要:

目的:观察冠心病患者血液流变学、氧化低密度脂蛋白、氧自由基变化及其相关性。方法:择期开腹手术患者64例,冠心病组和对照组各 32例,同时监测血液流变学的变化、氧化低密度脂蛋白(ox-LDL)、脂质过氧化物(LPO)和超氧化物歧化酶(SOD)等指标。结果:冠心病组全血高切黏度、低切黏度、红血细胞压积、红细胞变形指数和 oxLDL,均显著高于对照组(P<0.05或 P<0.01);且全血高切黏度、低切黏度及红血细胞压积与ox-LDL间呈显著正相关(P<0.05);与对照组相比,冠心病组 LPO活性增高(P<0.05),SOD活性降低(P<0.05)。结论:冠心病患者在血液流变学异常变化的同时,伴有 ox-LDL和 LPO活性增高,SOD活性降低,且血液流变学变化与 ox-LDL间呈正相关。

Abstract:

AIM:To observe the changes in hemorreology and their correlation with the changes in oxidated low-density lipoprotein(ox-LDL) and free raical in coronary heart disease patients. METHODS: 64 patients who had unergone aboominal surgery were ranomly divided into 2 groups: the coronary heart disease group(n=32) and the control group(n=32). And the changes in hemorrheology, ox-LDL,lipoperoxide(LPO) and superoxied ismutase(SOD) were observe. RESULTS: The whole blood high-shears viscosity, low-sheard viscosity, hematocrit, distortion index of red blood cells and ox-LDL were significantly higer in the coronary heart disease group (P<0.05 or P<0.01), and there was positive correlation between high-sheard viscosity,low-sheard viscosity, hematocrit and ox-LDL(P<0.05). Compared with the contiol group, the activity of LPO increased (P<0.05) and the activity of SOD decrease (P<0.05) in the coronary heart disease group. CONCLUSION: There were abnormal changes in hemorreology in the coronary heart disease group, with the activities of ox-LDL and LPO increaseing and the activity of SOD decreasing. And the changes in hemorrheology were correlated with ox-LDL.

参考文献/References

[1]Chin JH,Azhar S,Hoffman BB.In activation of endothelial derived relaxing factor by oxidized lipoprotein[J].J Clin Invest,1992,89(1):10.

[2]杨成玉,陈刚.氧化低密度脂蛋白的临床研究进展[J].国外医学*临床生物化学与检验学分册,2000,21(1):18.

[3]霍海洋,李淑琴,余东颖,等.冠心病患者过氧化低密度脂蛋白水平测定及意义[J].中国实用内科杂志,1996,16(7):422-423.

[4]何玉泉.动脉粥样硬化发生机制的现代观点[J].国外医学*心血管疾病分册,1994,21(5):279.

备注/Memo

备注/Memo:

收稿日期：2002-12-30

常用功能

更新日期/Last Update: 2004-01-01