我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

小剂量胺碘酮治疗室性心律失常疗效与QT间期的相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第2期
页码:
135-136,139
栏目:
临床研究
出版日期:
2004-03-01

文章信息/Info

Title:
Correlation between efficacy of a low-loading dose of Amiodarone in the treatment of ventricular arryth mias and QT interval
作者:
寿锡凌1; 肖刚2; 李宏波1; 梁磊1; 陈新义1; 官功昌1; 王亚丽1; 刘新宏1
.陕西省人民医院心内科,陕西 西安 710068; 2.中共陕西省委机关医院
Author(s):
SHOU Xi-ling1; XIAO Gang2; LIHong-bo1; LIANG Lei1; CHEN Xin-yi1; GUAN Gong-chang1; WANG Ya-li1; LIU Xin-hong1
1.Department of Cardiology, Shaanxi people's Hospital, Xi'an, Shaanxi 710068, China
关键词:
心律失常; 室性; 胺碘酮; QT间期
Keywords:
ventricular arrythmias;  Amiodarone;  QT interval
分类号:
R541.7
DOI:
-
文献标识码:
A
摘要:
目的:探讨小剂量胺碘酮治疗室性心律失常疗效与QT间期的关系。方法:48例室性心律失常患者给予小剂量胺碘酮,疗程4个月,观察治疗前后患者室性心律失常有效控制率与QT间期延长的关系以及不良反应。结果:48例患者治疗有效率高达90%,且维持量小(143±34mg/d)。仅1例出现一过性T3、T4升高,余无其它不良反应。QT间期延长者治疗效果满意;QT间期未延长者,治疗效果不佳,经延长负荷期后可使部分患者QT间期延长而取得满意疗效。结论:小剂量胺碘酮治疗室性心律失常的疗效确切,维持用量小,不良反应少,且QT间期延长者胺碘酮疗效较佳。
Abstract:
AIM:To evaluate the efficacy of a low-loading dose of Amiodarone in the treatment of ventricular arrythmias (VA). METHODS: Forty-eight patients with VA were treated with Amiodarone for four months. A low-loading dose of Amiodarone was givenf or fourteen days or more. The therapeuti cefficacy, QT interval and side-effects were observe. RESULTS: The total effective rate of patients with VA was 89.6%. Only one patient developed hyperthy roidism and recovered after the treatment. No otherside-effects due to Amiodar one were observed. The therapy was more effective inpatients with QT interval prolongation. If VA was no tcontrolled in patients with normal QT interval, QT interval was prolonged after additional loading dose of Amiodarone and VA was controlled. CONCLUSION:T here was obvious the rapeutic efficacy of a low-loading dose of Amiodarone in the treatment of ventricular arrythmias. No severe side-effects weref ound. The main taining dose was lower.QT interval prolongation was very important for therapeutic efficacy.

参考文献/References

[1]Julian DG,Camm AJ,Frangin G,et al.Randomized trial of effect of Amiodarone on mortality in patients with left ventricular dysfunction after recent myocardial infarction: EMIAT[J].Lancet,1997,349:667-674.

[2]Singh SN,Fletcher RD,Fisfker SG,et al.Amidarone in patients with congestive heart failure and asymptomatie ventricuiar arrhythmia[J].N Engl J Med,1995,333:77-82.

[3]Kerin NZ,Aragon E,Faitel K,e tal.Long-term efficacy and toxicity of high and low-dose Amiodarone regimens[J].J Clin Pharmacol,1989,29:418-423.

[4] Cairns JA, Connolly SJ, Roberts RS, etal. Canadian Amiodarone myocardial infarction arrhythmia trial investigators.Randomizeds trial of outcome after myocardial infarction in patients with frequentor repetitive ventricular premature depolarization: CAMIT[J]. Lancet,1999,353:9-13.

[5]Chuang CL,Chern MS,ChangS C,et al.Amiodarone toxicity in apatient with simultaneous in volvement of cornea, thyroid gland,and lung[J].Am J Med Sci,2000,320(1):64-68.

[6]Loh KC.Amiodarone-induced thyroid disorders: a clinical review[J]. Postgrad Med J,2000,76(893):133-140.

[7]Doval HC,Nul DR,Grancelli HO,et al.Randomized trial of low-dose amidarone in severe congestive heart failure[J].Lancet,1994,344:493-498.

[8]Vorperian VR,Havighurst TC,Miller S,et al.Adverse effects of low dose Amiodarone: ameta-anlysis[J].J Am Coll Cardiol,1997,30(3):791-798.

备注/Memo

备注/Memo:
收稿日期：2003-5-12
更新日期/Last Update: 2004-03-01