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|本期目录/Table of Contents|

T2DM 颈动脉粥样硬化与血尿酸关系(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第2期
页码:
132-134
栏目:
临床研究
出版日期:
2004-03-01

文章信息/Info

Title:
The relationship between uricacid and carotid atherosclerosis in T2DM
作者:
王莉; 赵霞; 张南雁; 孙会会; 孟凡江; 李德强; 赵魁彦; 陈非; 姬秋和
第四军医大学西京医院内分泌科,陕西 西安 710032
Author(s):
WANG Li; ZHAO Xia; ZHANG Nan-yan; SUN Hui-hui; MENG Fan-jiang; LI De-qiang; ZHAO Kui-yan; CHEN Fei; JI Qiu-he
Department of endocrinology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032,China
关键词:
Ⅱ型糖尿病; 颈动脉粥样硬化; 尿酸
Keywords:
type 2 diabetes mellitus;  carotid atherosclerosis;  uricacid
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的:探讨Ⅱ型糖尿病(T2DM)患者血清尿酸水平变化与颈动脉粥样硬化的关系。方法:检测102例Ⅱ型糖尿病患者病程、空腹血糖、餐后血糖、体质量指数(BMI)、血压、血清胆固醇、甘油三脂、尿酸、肾功5项、心脏收缩和舒张功能。按是否有动脉粥样硬化分为2组。结果:在T2DM 并发动脉粥样硬化组血清尿酸水平显著升高(P<0.01),心脏舒张功能显著降低(P<0.01),尿β2、α2微球蛋白,ALb排泄增加(均P<0.01)。结论:T2DM 患者颈动脉粥样硬化时血清尿酸水平升高,同时伴心脏舒张功能损伤,这种尿酸变化可能与肾小管的损伤有关。
Abstract:
AIM:To investigate the association between serum uricacid concentration and carotid atherosclerosis in type 2 diabetes mellitus (T2DM). METHODS: A study of 102 T2DM patients with or without carotid atherosclerosis was performed. Age, duration, free blood glycose(FBG), post prandial bloodg lycose(PBG), body-mass index(BMI), blood pressure (BP), serum cholesterol(TC), triglyceride(TG), uricacid(UA), serum β2-microglobulin(β2-GM), urinary β2-microglobulin(β2-GM), urinary α2-microglobulin(α2-GM), albuminuria (Alb), urinary immunoglobulin(Ig), leftventricular systolic and diastolic function were analyzed. RESULTS: The level of uricacid and uriary excretion of β2-GM, α2-GM, albuminuria (Alb significantly increased in T2DM patients with carotid therosclerosis, while left ventricular diastolic function significantly decreased. CONCLUSION: The increased level of serum uricacid was likely associated with the injury of renaltubule.

参考文献/References

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[4]Nieto FJ,Iribarren C,Gross MD,et al.Uricacid and serum antioxidant capacity: a reaction to therosclerosis? [J].Atherosclerosis,2000,148:131-139.

[5]Ruilope LM,Puig JG.Hyperuricemia and renal function[J].Curr Hypertens Rep, 2001,3(3):197-202.

[6]Langlois M,Bacquer DD,Duprez D,et al.Serum uricacidinhypertensive patients with and withoutperipheralarterial disease[J]. Atherosclerosis, 2003,168(1):163-168.

[7]Mattock MB,Barnes DJ,Viberti GC,et al.Microalbuminuria and coronary heart disease in NIDDM[J].Diabetes,1998,47(11):1786-1792.

[8]张庆,曾智.内皮细胞凋亡与动脉粥样硬化[J].心脏杂志,2002,14(4):356.

[9]Liu JE,Robbins DC,Palmieri V,et al.Association of albuminuria with systolic and diastolic left ventricular dysfunction in type 2 diabetes-The Strong Heart Study[J].J Am Coll Cardiol,2003,41(11):2022-2028.

备注/Memo

备注/Memo:
收稿日期：2003-9-18
更新日期/Last Update: 2004-03-01