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热应激对兔慢性心力衰竭血浆NOS与血流动力学的实验研究’ (PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第3期
页码:
217-220
栏目:
实验研究
出版日期:
2004-05-01

文章信息/Info

Title:
Experimental study of the effects of heat stress on NOS of plasma and hemodynamic in rabbits with chronic heart failure
作者:
陶卫国1; 傅向阳1;  黄巧冰2; 傅强1; 罗斌德3; 李公信1
第一军医大学:1.珠江医院心内科，2.病理生理学教研室，3.热卫系，广东 广州 510282
Author(s):
TAO Wei-guo; FU Xiang-yang; HUANG Qiao-bing; FU Qiang; LUO Bin-de; LI Gong-xin
Department of Cardiology, Zhujiang Hospital，First Military Medical University，Guangzhou Guangdong 510282,China
关键词:
热应激; 慢性心衰; 一氧化氮合膝; 血流动力学
Keywords:
heats tress; chronic heart failure; NOS; hempdynamic
分类号:
R541. 6
DOI:
-
文献标识码:
A
摘要:
目的:探讨热应激对慢性心衰家兔血流动力学与血浆一氧化氮合成酶(NOS)的影响。方法:新西兰兔25只作冠状动脉结扎(CAL)，另外5只作对照，不作结扎为假手术组。冠脉结扎后8周，CAL组25只兔随机分为常温对照组(n=5),L-NAME组(n=5)，左旋精氮酸(L-Are)组(n=5)，热应激组(n=5)，热应激+左旋硝基精氮酸甲醋(LNAME)组(n=5)，并测定血流动力学、血浆NOS.然后将动物放置在温度42℃，待肛温达到42℃，维持15-20min，热应激结束后，将动物移到常温环境下，分别测定热应激终止后2,4,8,24 h的血流动力学及血浆NOS,结果:①CAL组血流动力学与假手术组比较差异非常显著(P<0.01 ).②热应激组24h 后血流动力学与对照组比较有改善;热应激+L-NAME组血流动力学与对照组比较无改善，常温+ L-Arg组血流动力学与对照组比较有改善。③CAL组血浆NOS比假手术组高(P<0 .01 ).结论:热应激作用于慢性心衰后有保护心肌作用，改善血流动力学，其与升高的NOS有关。
Abstract:
AIM:To investiagte the effects of heat strss on nitric oxide synthase of plasma and hemdynamicin rabbits with chronic heart failure. METHODS: coronary arteries of twenty-five rabbits were ligated(CAL)，and thorax of five rabbits (sham group) were only operated on but not ligated. The 25 rabbits were divided into control group(n=5),L-NAME group(n=5)，L-Arg group (n=5),heat stress(HS) group(n=5)，HS+ LNAME group(n=5).Hemodynamic and NOS of plasma are examinated 8 weeks after CAL,then heat stress animals were placed in room where temperature about 42 ℃，and the animals will be taken out until recta temperature ofthe animals is about 42 ℃，and continous 15-20 min. Hemodynamic and NOS of plasma of heart failure animats were examinated 2，4, 8，24 hours after heat stress. RESULTS: ①Hemodynamic of CAL groups are deteriorative than that of sham group follow 8 weeks (P<0.01).②Hemodynamic of HS group were improved follow heat stress 24 hours (P<0. 01).③ NOS of plasma in CAL groupsis higher than sham group 8 weeksafter CAL(P<0.01).④NOS of plasma in heat stress groups is elevated 24 hours after heat stress than those of control group and before heat stress(P<0.01). CONCLUSION: Heats tress influenced chronic heart failure can play arole of protecting myocardium and can improve hemodynanmic. That may be related to high NOS of plasma.

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备注/Memo

备注/Memo:
收稿日期：2003-12-23
更新日期/Last Update: 2004-05-01