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冠心灵对冠脉血流量、心肌收缩力和心电活动的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2004年第4期
页码:
323-326
栏目:
基础研究
出版日期:
2004-07-01

文章信息/Info

Title:
The effects of Guanxinling on coronary blood flow，contraction force of cardiac muscle and electrical activity of the heart
作者:
陆红丽1; 李慈珍1; 刘远谋1; 翁恩琪2; 刘赟2
1.上海第二医科大学生理学教研室，上海 200025; 2.华东师范大学环境卫生系，上海 200063
Author(s):
LU Hong-li1; LI Ci-zhen1; LIU Yuan-mou1; WENG En-qi2; LIU Bin2
1.Department of Physiology, Shanghai Second Medical University, Shanghai 200025，China; 2. Department of Environment and Sanitary, China East Normal University，Shanghai 200063，China
关键词:
冠心灵; 慢反应动作电位; Langendorff灌流; 心率变异性
Keywords:
guanxinling; slow response action potential; Langendorff-perfused; heart rate variability
分类号:
R285.5
DOI:
-
文献标识码:
A
摘要:
目的:研究中药复方制剂冠心灵的心血管作用并初步探讨其作用机制。方法:运用细胞内徽电极技术、Langendorff离体心脏灌流和心率变异性功率谱分析等方法，研究冠心灵对心肌细胞动作电位的形响;观察其对冠脉血流且和心肌收缩力的作用;分析冠心灵对冠心病患者心率变异性的影响.结果:冠心灵增强Ca2+跨膜内流，增加冠脉血流A和心肌收缩力，改普因缺血导致冠脉流it和心肌收缩力的下降;功率谱分析显示心迷走交感对心率的调控作用比升高.结论:冠心灵有改善心肌缺血的作用。
Abstract:
AIM:Observe the cardiovascular effects of guanxinling capsule and discuss the possible mechanism. METHODS:Conventional microelectrode technique and Langendorff-perfused guinea-pig hearts were used. After patient taking capsules of guanxinling for 3 months，ECG were recorded and analyzed with heart rate variability (HRV) power spectrum analysis. RESULTS: Guanxinling could increase the Ca2+ inward current. Guanxinling could increase the coronary blood flow，enhance the strength of contraction of the heart without obviously changing the heart rate. Guanxinling could also antagonise the negative effects produced by mimic ischemia. The ratio of cardiac parasympathetic tone to sympathetic tone is significantly increased by guanxinling. CONCLUSION:It indicates that guanxinling can protect ischemic myocardium.

参考文献/References

[1] Li CZ, Wang XD, Wang HW, et al. Four types of late Na channel currentin isolated ventricular myocytes with reference to their contribution to the lastingness of action potential plateau[J].Acta Physiologica Sinica,1997,49(3):241-248.

[2] Ferrier GR, Moffat MP, Lukas A. Possible mechanisms of ventricular arrhythmiase licited by ischemia followed by reperfusion. Studies on isolated canine ventricular tissues[J].Circ Res, 1985,56(2):184-194.

[3] Allaart CP, Westerhof N. Effect of length and contraction on coronary perfusion in isolated perfused papillary muscle of rat heart[J].Am J Physiol,1996,271(2 Pt 2):H447-H454.

[4] 刘启曹，蔡体导.丹参酮Ⅱ-A磺酸钠对分离的豚鼠心室肌单细胞慢反应动作电位的作用[J].生理学报，1990,42(3):254-261.

[5] 王书睦，农艺，夏国班，等.莲心碱对心肌慢反应动作电位及慢内向电流的形响[J].药学学报，1993,28(11):812-816.

[6] Ashruf JF, Ince C, Bruining HA. Regional ischemia in hypertrophic Langendorff-perfused rat hearts[J].Am J Physiol,1999,277(Heart Circ.Physiol.46): H1532-H1539.

[7] Hulsmann WC, Ashruf JF, Bruining HA, et al. Imminent ischemia in normal and hypertrophic Langendorff rat hearts: effects of fatty acids and superoxide dismutasem onitored by NADH surface fluorescence[J].Biocim Biophys Acta, 1993,1181(3 :273-278.

[8] 陈伯钧，张敏州，黄春林，等.心纹痛[A].黄春林.心血管科专病中医临床诊治[M].北京:人民卫生出版社，2000.1-39.

[9] Bigger JT Jr, Fleiss JL, Steinman RC, et al. RR variability in healthy, middle-age persons with patients with chronic coronary heart disease or recent acute myocardialin farction[J].Circulation. 1995,91(7):1936-1943.

[10] 赵国定，王宏亮，杨德青，等.冠心灵三号方治疗冠心病131例[J].辽宁中医杂志，1999,26(3):103.

[11] 陆再英，屈建石.心率变异性[A].陈新.临床心律失常学电生理和治疗[M].北京:人民卫生出版社，2000.249-291.

备注/Memo

备注/Memo:
收稿日期：2003-7-7
更新日期/Last Update: 2004-07-01