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|本期目录/Table of Contents|

左旋卡尼汀对异丙肾上腺素致心肌损害的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第1期
页码:
13-15
栏目:
基础研究
出版日期:
2005-01-05

文章信息/Info

Title:
Protective effect of Lcarnitine on myocardial damage induced by isoproterenol
作者:
钱伟1;  殷仁富1; 任建平2; 顾书华3
1.第二军医大学长征医院心内科，上海 200003；2.军事医学科学院二所, 北京 100850；3.常州三维工业技术研究所，江苏 常州 213022
Author(s):
QIAN Wei1;  Yin Renfu1;  REN Jianping2;  GU Shuhua3
1.Department of Cardiology, Changzheng Hospital, Second Military Medical University, Shanghai, 200003; 2. Second institute, Academy of Military Medical Sciences, Beijing 100850；3. Sanwei Technical Research Laboralory, Changzhou,Jiangsu 213022
关键词:
左旋卡尼汀; 异丙肾上腺素; 线粒体; 膜脂流动性
Keywords:
Lcarnitine;  isoproterenol;  mitochondria;  membrane lipid fluidity (LFU)
分类号:
R541.6
DOI:
-
文献标识码:
A
摘要:
目的 观察左旋卡尼汀对异丙肾上腺素致心肌损害的保护作用并探讨其机制。方法 采用大鼠皮下注射异丙肾上腺素造成心肌损害模型。心肌切片，HE染色，光镜下观察心肌损害程度；分离心肌线粒体，测定膜脂流动性（LFU）。结果 注射左旋卡尼汀可减轻心肌损害程度；改善线粒体的损伤，改善LFU。结论 左旋卡尼汀能减轻异丙肾对心肌的损害，对线粒体膜脂流动性损伤具有明显的保护作用。
Abstract:
AIM To investigate the protective effect of Lcarnitine on myocardial damage induced by isoproterenol and its mechanism. METHODS Rat myocardial ischemia was induced by isoprenaline(ISO) 5 mg/kg injected subcutaneously. Sections of heart were stained with hematoxylin eosin and the degree of myocardial damage was evaluated under the microscope. Rat myocardial mitochondria were isolated, and membrane lipid fluidity (LFU) was determined. RESULTS The degree of myocardial damage was significantly reduced in the groups treated and pretreated with Lcarnitine. Injury of myocardial mitochondra was attenuated in the Lcarnitine group. CONCLUSION Lcarnitine may protect the myocardium from damage by isoproterenol and may also have protective effect on LFU of mitochondria damaged by ISO.

参考文献/References

［1］ Bartels GL, Remme WJ, Schlote HR. Acute myocardial ischemia induces cardiac carnitine release in man［J］. Eur Heart J, 1997, 18:84.

［2］ Pepine CJ. The therapeutic potential of carnitine in cardiovascular disorders［J］. Clin Ther， 1991,13(1):2-21.

［3］ 陈景元, 龚书明, 高双斌, 等. 运动对大鼠心肌线粒体H+转运ATP酶活性及膜流动性的影响［J］. 第四军医大学学报, 1994, 15(2): 105-107.

［4］Saks VA, Khuchua ZA, Kuznetsov AV, et al. Heart mitochondria in physiological salt solution: not ionic strength but salt composition is important for association of creatine kinase with the inner membrane surface［J］. Biochem Biophys Res Commun, 1986,139(3):1262-1271.

［5］ Kondo T, Ogawa Y. Sugiyama S, et al. Mechanism of isoproterenol induced myocardial damage［J］. Cardiovasc Res, 1987, 21: 248.

［6］ Willis WT, Brooks GA, Henderson SA, et al. Effects of iron deficiency and training on mitochondrial enzymes in skeletal muscle［J］. J Appl Physiol, 1987, 62(6): 2442.

备注/Memo

备注/Memo:
收稿日期：2004-04-19.
更新日期/Last Update: 2010-01-05