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替米沙坦改善原发性高血压病患者心肌肥厚及早期肾功能失调(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第1期
页码:
39-41
栏目:
临床研究
出版日期:
2005-01-05

文章信息/Info

Title:
Effect of Telmisartan on left ventricular hypertrophy and earlier period renal dysfunction in patients with essential hypertension
作者:
于海波1韩雅玲2高柏青3佟铭2张新娅2王祖禄2许凤芝2
1.第四军医大学西京医院心血管内科,陕西 西安710032;沈阳军区总医院:2.心血管内科, 3.干诊科, 辽宁 沈阳110016
Author(s):
YU Haibo1 HAN Yaling2 GAO Baiqing3 TONG Ming2 ZHANG Xinya2WANG Zulu2 XU Fengzhi2
1.Department of Cardiology,Xijing Hospital,Fourth Military Medical University,Xi'an,Shaanxi 710032,China; 2.Department of Cardiology; 3.Department of Geriatrics, General Hospital of Shenyang Command of PLA, Shenyang, Liaoning 110016,China
关键词:
高血压替米沙坦心肌肥厚
Keywords:
hypertension telmisartan left ventricular hypertrophy
分类号:
R541.3; R972.4
DOI:
-
文献标识码:
A
摘要:
目的 评估替米沙坦在高血压病靶器官损害中的保护作用。方法 轻中度原发性高血压病左室肥厚患者60例服用替米沙坦40~80 mg/d,共26周,服药前后行超声心动图,观察舒张末期室间隔厚度(IVST),舒张末期左心室后壁厚度(LVPWT)及A/E比值的变化;并计算左室心肌质量指数(LVMI)的改变;同时放射免疫分析法测量血β2微球蛋白(β2MG)、尿β2MG含量。结果 替米沙坦能有效降低血压,降压有效率为72%,治疗后LVMI降低(146±12 vs 123±10)(P<0.01),A/E值改善(P<0.05),血、尿β2MG水平降低。结论 替米沙坦在降低血压同时能够有效地保护心肾功能。
Abstract:
AIM To evaluate the effect of Telmisartan on target organ damage in patients with mild to moderate hypertension. METHODS 60 patients with mild to moderate hypertension complicated with left ventricular hypertrophy were treated with Telmisartan for 26 weeks. The IVST,LVPWT,A/E,LVMI were checked by echocardiography and the concentrations of serum β2MG and urine β2MG were determined before and after treatment. RESULTS Both SBP and DBP decreased after the treatment of Telmisartan ,the effective rates were 72%, LVMI,A/E,serum β2MG and urine β2MG significantly decreased after Telmisartan treatment. CONCLUSION Telmisartan was effective not only in treating of hypertension but also in preventing heart and kidney from dysfunction.

参考文献/References

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[7]Ivanova OV, Fomicheva OA, Sergakova LM. Angiotensin II receptor blocker telmisartan: effect on 24-hour blood pressure profile and left ventricular hypertrophy in patients with hypertension [J]. Kardiologiia, 2002, 42(2):45-49.

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备注/Memo

备注/Memo:
收稿日期:2004-08-18.
更新日期/Last Update: 2010-01-05