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左旋卡尼汀治疗慢性充血性心力衰竭的疗效观察(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2005年第1期
页码:
49-51
栏目:
临床研究
出版日期:
2005-01-05

文章信息/Info

Title:
Effects of levocarnitine on congestive heart failure
作者:
何勇; 郑强荪; 张录兴; 金葵花
第四军医大学唐都医院心内科, 陕西 西安710038
Author(s):
HE Yong; ZHENG Qiangsun; ZHANG Luxing; JIN Kuihua
Department of Cardiology, Tangdu Hospital, Fourth Military Medical University ,Xi′an,Shaanxi 710038,China
关键词:
心力衰竭; 慢性; 充血性; L卡尼汀; 治疗
Keywords:
heart failure; chronic;  congestive;  levocanitine;  treatment
分类号:
R541.61
DOI:
-
文献标识码:
A
摘要:
目的 评价左旋卡尼汀(L卡尼汀)对慢性充血性心力衰竭(CHF)的治疗效果。方法 选择CHF患者136例随机分成2组，每组68例，对照组使用常规治疗方法，卡尼汀组加用L卡尼汀，治疗10 d后比较NYHA心功能分级及心脏指数、左室射血分值和E/A改善情况。结果 ①两组治疗后均有效，心功能显著改善。②治疗组的总有效率明显优于对照组（89% vs 70%，P<0.05）；心功能改善更为显著（P<0.05）。结论 CHF患者短期适量补充外源性卡尼汀有益于改善心功能。
Abstract:
AIM To evaluate the clinical effect of levocanitine on congestive heart failure(CHF). METHSODS 136 CHF patients were divided into two groups randomly, each consisting of 68 patients. In the control group (n=68), patients were treated with commonly used drugs. In the levocanitine group (n=68), patients were treated with conventionally used drugs and levocanitine. NYHA cardiac function grade, cardiac index, ejection fraction and E/A were compared 10 days later. RESULTS ①Both treatments were effective for CHF， and cardiac function was improved. ②Effective rate of the levocanitine group,whose cardiac function was improved significantly(P<0.05), was higher than that of the control group(89% vs 70%, P<0.05). CONCLUSION Appropriate endogenous levocanitine is beneficial to the improvement of the cardiac function of CHF patients.

参考文献/References

［1］ Bremer J. Carnitine metabolism and function ［J］. Physiol Res, 1983,63:1420-1428.

［2］ Regitz V, Shug AL, Fleck E. Defective myocardial metabolism in congestive heart failure secondary to dilated cardiomyopathy and to coronary hypertensive and valvular heart disease［J］. Am J Cardiol,1990,65: 755-803.

［3］ Yusuf S, Sleight P, Pogue J, et al. Effects of angiotensin-converting enzyme, ramipil, on cardiovascular events in high 0risk patients. The Heart Outcomes Prevention Evaluation Study Investigators［J］. N Engl J Med, 2000,342(3):145-153.

［4］ Pott B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure ［J］. N Engl J Med, 1999,341;709-717.

［5］ Anand I , Chandranshekhan Y , De Giuli F , et al. Acute and chronic effects of propionylcarnitine on the hemodynamics, exercise capacity , and hormones in patients with congestive heart failure［J］. Cardiovasc Drugs Ther, 1988,12:291-308.

［6］ 殷仁富，王咏梅，陈金明，等. 国产左旋卡尼汀改善慢性充血性心力衰竭患者心功能的临床研究［J］．第二军医大学学报，2001,(2):173-178.

备注/Memo

备注/Memo:
收稿日期：2003-08-27.
更新日期/Last Update: 2010-01-05