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高钙摄入和辛伐他汀对大鼠主动脉和骨组织脂、钙代谢的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第1期
页码:
43-46
栏目:
基础研究
出版日期:
2006-01-01

文章信息/Info

Title:
Effect of high calcium and simvastatin on metabolism of lipid and calcium in artery and bone of SD rats
作者:
卢维晟; 王一尘; 方根强; 沈丽
上海交通大学医学院附属新华医院老年科,上海 200092
Author(s):
LU Wei-sheng; WANG Yi-chen; FANG Gen-qiang; SHEN Li
eptartment of Geriatrics, Xinhua Hospital of Shanghai Jiaotong University,Shanghai 200092，China
关键词:
动脉硬化; 血管钙化; 钙沉积; 辛伐他汀
Keywords:
atherosclerosis; artery calcification; calcium aggradation; Simvastatin
分类号:
R543.5
DOI:
-
文献标识码:
A
摘要:
目的 探讨大量钙的摄入和促进骨钙沉积的措施是否会加重动脉粥样硬化、血管钙化及辛伐他汀对其影响。方法 健康雄性SD大鼠44只，体质量150~200 g。随机分为5组：空白对照组（n=8）；VitD3对照组（n=9）；高脂组（n=9）；高脂高钙组（n=9）；辛伐他汀组（n=9），比较各组动物血脂、血钙，血管钙、骨钙含量水平和进行主动脉病理学检测。结果 高脂高钙组与高脂组相比，血管钙和骨钙含量均显著升高（P<0.05）。辛伐他汀组与高脂高钙组相比，血管钙显著降低（P<0.01），骨钙显著升高（P<0.01）。Von Kossa特殊钙染色法也在血管病理学上得出了相同结果。结论 大剂量VitD3灌胃并高脂饲料的基础上，采用高钙摄入能加重动脉粥样硬化和骨组织的钙化。辛伐他汀在改善骨钙化的同时，能起到减轻血管钙化的作用。
Abstract:
AIM To explore whether high intake of calcium will aggravate atherosclerosis and artery calcification and whether Simvastatin will ameliorate artery calcification and calcium in bone aggradation. METHODS Fortyfour male SD white rats, with body weight of 150~200g, were divided into five groups at random:①baseline group (n=8);②VitD3 group (n=9); ③highcholesterol diet group(n=9); ④highcholesterolcalcium diet group(n=9); ⑤Simvastatin group(n=9). The measurement of plasma levels of cholesterol, triglyceride and calcium, calcium content in artery and bone, and pathologic observations of arteries were made. RESULTS Compared with highcholesterol diet group,the highcholesterolcalcium diet group, evidently had higher calcium content in both artery and bone (P<0.05).Compared with highcholesterolcalcium diet group, the Simvastatin group, evidently had lower content of artery calcium, and higher content of bone calcium instead (P<0.01), which was also confirmed by observed pathologic changes of arteries using Von Kossa method. CONCLUSION Highcalcium intake aggravates atherosclerosis and artery calcification and simvastatin ameliorates arterial calcification and calcium in bone aggradation.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2005-01-20.作者简介：卢维晟，硕士Tel：（021）65790000-7415 Email：weiyu19781@126.com
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