温度对心脏自律性的影响机制(PDF)
《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]
- 期数:
- 2006年第2期
- 页码:
- 123-127
- 栏目:
- 基础研究
- 出版日期:
- 2006-03-01
文章信息/Info
- Title:
- Mechanism for temperatureinduced change of spontaneous heart beating
- Author(s):
- YAN Yu-feng; LI Hu-sheng; LI Ci-zhen ; LIU Yuan-mou
- Department of Physiology，Schoole of Medicine， Shanghai Jiaotong University，Shanghai 200025
- 分类号:
- Q463;R331.38
- DOI:
- -
- 文献标识码:
- A
- 摘要:
- 目的 探讨温度对心脏自律性的影响机制。方法 心率变异性（HRV）功率谱分析、细胞内动作电位记录和放射免疫法测窦房结组织内环磷酸腺苷（cAMP）含量。结果 温度变化前后，人和家兔的LF/HF都没有显著差异；温度升高，可使窦房结细胞动作电位的4期自动除极速率加快，窦房结组织内的cAMP含量增加；在窦房结主要离子流If、Ik、ICa·T中，If对温度的变化最为敏感。结论 温度对心率的影响并非通过神经因素，而是由温度对窦房结的直接作用所致，并且这一作用可能与cAMP对If电流的调控有关。
- Abstract:
- AIM To study how temperature affects pacemaker activities of sinusnode cells. METHODS Heart rate variability (HRV) power spectrum analysis, action potential recording and radioimmunoassay were employed. RESULTS LF/HF had not changed significantly with different temperatures, while the higher temperature could both directly increase the spontaneous depolarization rate of SAN cells and the concentration of cAMP in the SAN preparations. Among the major pacemaker currents (If, IK, ICa·T), If was the most sensitive one to the changes of temperature. CONCLUSION The changes of temperature directly act on SAN cells instead of via nervous mechanism, and intracellular cAMP may mediate this effect.
参考文献/References
［1］Collins DR, Korsak A, Gilbey MP. Cutaneous sympathetic motor rhythms during a feverlike response induced by prostaglandin E(1)［J］. Neuroscience,2002,110(2):351-360.
［2］ Pakhomov AG , Mathur SP , Doyle J, et al. Comparative effects of extremely high power microwave pulses and a brief CW irradiation on pacemaker function in isolated frog heart slices［J］. Bioelectromagnetics, 2000, 21(4): 245-254.
［3］ 陆红丽，李慈珍，刘远谋，等. 冠心灵对冠脉血流量、心肌收缩力和心电活动的影响［ J］. 心脏杂志, 2004,16(4):323-326.
［4］ 杨智昉，李慈珍，李倩,等. 出生后心率变慢的窦房结调控机制［J］. 生理学报,2002, 54(4):282-286.
［5］ Rosenbaum T, Gordon SE. Quickening the pace: looking into the heart of HCN channels［J］. Neuron, 2004, 42(2):193-196.
［6］ Nikonenko I, Bancila M, BlOC A, et al. Inhibition of Ttype calcium channels protects neurons from delayed ischemiainduced damage［J］. Mol Pharmacol，2005,68（1）：84-89.
［7］ 李慈珍,刘远谋, 杨智昉. Cs离子对家兔窦房结If和Ik及自律性的影响［J］. 生理学报,1998 ,50(4):409-415.
备注/Memo
- 备注/Memo:
- 收稿日期：2005-03-14.基金项目：国家自然科学基金项目资助（No.30270498） 上海市卫生局基金项目资助（No.024078）通讯作者：刘远谋，教授,主要从事心脏电生理方面的研究 Tel：(021)64672079 作者简介：严钰锋，博士生 Tel：（021）63846590776447 Email：yyfyanyufeng@msn.com
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