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新型人工心脏辅助装置材料组织炎症反应观察(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第2期
页码:
146-148
栏目:
基础研究
出版日期:
2006-03-01

文章信息/Info

Title:
Application of hardsegment modified PU in ventricule assisted device
作者:
刘金成; 易定华;  徐学增;  崔勤; 董小超
第四军医大学西京医院全军心血管病研究所心血管外科，陕西 西安 710032
Author(s):
LIU Jin-cheng;  YI Ding-hua;  XU Xue-zeng;  CUI Qin;  DONG Xiao-chao
Department of Cardiovascular Surgery, Institute of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi′an,Shaanxi 710032, China
关键词:
心室辅助装置; 生物材料; 炎症反应
Keywords:
ventricular assist device; biomaterial;  inflammatory reaction
分类号:
R654.2
DOI:
-
文献标识码:
A
摘要:
目的 观察用于制造人工心脏辅助装置的硬段相、软段相改性新型聚氨酯材料和未改性医用聚氨酯材料的组织炎症反应程度。方法 选用材料硬度90A的硬段相改性医用聚氨酯（A组）、软段相改性医用聚氨酯（B组）和未改性医用聚氨酯材料（C组）组装成人工心脏辅助装置，建立犬心脏辅助转流模型。观察转流不同时间后心、 肝、 脾、 肺、 肾标本组织学变化，并测定不同转流时间后血液炎性因子（IL-6、IL-8、TNFα）含量。结果 转流72 h后C组组织炎症充血、水肿，炎症反应明显强于A、B两组。48 h内体内IL-6、IL-8、TNFα炎性因子水平呈升高趋势，C组明显高于A、B组。 48 h后各组炎性因子水平趋于稳定。结论 硬段相改性医用聚氨酯材料比未改性的常见医用聚氨酯材料组织炎症反应轻微， 具有良好的血液相容性，可作为人工心脏辅助装置的首选材料进一步推广应用。
Abstract:
AIM To observe the inflammatory reaction of 90A consistency, softsegment modified PU and pure PU, which were assembled into a ventricule assisted device (VAD). METHODS The animal left ventricular experiment models were established with canines and VAD, which was made from hardsegment modified PU (group A), soft segment modified PU (group B) and pure PU (group C). At different time points, histological changes were observed and inflammatory factors tites including IL6, IL8 and TNFα were measured. RESULTS Group C had the worse inflammatory reaction compared with Group A and B. The levels of inflammatory factors of IL6, IL8 and TNFα showed a light rising tendency within 48 hours and were higher in group C than those in group A and B (P<0.05). The levels of these inflammatory factors stayed in a stable level after 48 hours of assisted circulation. CONCLUSION Hardsegment modified PU has only milder inflammatory reaction but better haemocompatibility than those of pure PU and can be the first choice of VAD material for wide application.

参考文献/References

［1］Abraham GA, de Queiroz AA, San Roman J. Immobilization of a nonsteroidal antiinflammatory drug onto commercial segmented polyurethane surface to improve haemocompatibility properties［J］. Biomaterials, 2004,23(7):1625-1638.

［2］Kalltorp M, Oblogina S, Jacobsson S，et al. In vivo cell recruitment, cytokine release and chemiluminescence response at gold, and thiol functionalized surfaces［J］. Biomaterials,2004,20(22):2123-2137.

［3］Chandy T, Das GS, Wilson RF, et al. Surfaceimmobilized biomolecules on albumin modified porcine pericardium for preventing thrombosis and calcification［J］. Int J Artif Organs,1999,22(8):547-558.

［4］Chang CC, Lieberman SM, Moghe PV. Leukocyte spreading behavior on vascular biomaterial surfaces: consequences of chemoattractant stimulation［J］. Biomaterials, 1999, 20(3):273-281.

［5］Engelberts I, Francot GJ, Leunissen KM,et al. Effect of hemodialysis on peripheral blood monocyte tumor necrosis factoralpha, interleukin6, and interleukin8 secretion in vitro［J］. Nephron, 1994,66(4):396-403.

［6］Mahiout A, Courtney JM. Effect of dialyser membranes on extracellular and intracellular granulocyte and monocyte activation in ex vivo pyrogenfree conditions［J］. Biomaterials, 1994 ,15(12):969-980.

［7］Steinberg BM, Grossi EA, Schwartz DS, et al. Heparin bonding of bypass circuits reduces cytokine release during cardiopulmonary bypass［J］. Ann Thorac Surg, 1995 ,60(3):525-529.

［8］Hasper D, Hummel M, Hetzer R, et al. Blood contact with artificial surfaces during BVAD support［J］. Int J Artif Organs,1996 ,19(10):590-596.

［9］Bouman CS, van Olden RW, Stoutenbeek CP. Cytokine filtration and adsorption during pre and postdilution hemofiltration in four different membranes［J］. Blood Purif, 1998,16(5):261-268.

［10］Gorelova NV. Spongy synthetic alloplast, porolon, as a substance for filling bone cavities［J］. Eksp Khir Anesteziol, 1966 ,11(1):7-8.

备注/Memo

备注/Memo:
收稿日期：2005-09-20.通讯作者：易定华,主任医师，教授，主要从事复杂先心病、心脏瓣膜病以及心脏移植方面的研究 Tel:(029)84775307 Email:yidh@fmmu.edu.cn 作者简介：刘金成，主治医师，博士 Tel：(029)84775312 Email：liujch@fmmu.edu.cn
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