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血浆肾素-血管紧张素-醛固酮水平对心房颤动转复的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第5期
页码:
547-549
栏目:
临床研究
出版日期:
2006-10-25

文章信息/Info

Title:
Plasma renin, angiotensin II and aldosterone level affect sinus rhythm restoration in patients with persistent atrial fibrillation
作者:
贾新未1; 王晓娜2; 史红云1; 杜宇3
1.河北大学附属医院心内科，河北 保定 071000；2.保定市妇幼保健院心内科；3.保定市第二医院，河北 保定 071000
Author(s):
JIA Xin-wei;  WANG Xiao-na; SHI Hong-yun; DU Yu
Department of Cardiology,Affiliated Hospital, Hebei University, Baoding, Hebei 071000, China
关键词:
肾素; 血管紧张素II; 醛固酮; 胺碘酮; 心房颤动
Keywords:
renin; angiotensin II; aldosterone; amiodarone; atrial fibrillation
分类号:
R972
DOI:
-
文献标识码:
A
摘要:
目的 研究不同肾素、血管紧张素II和醛固酮（RAS）水平对持续性心房颤动转复的影响。方法 对持续性心房颤动患者，在使用口服胺碘酮转复后依转复效果分为转复成功组（n=19）和转复未成功组（n=17），比较两组患者血浆RAS浓度水平。进一步分析其浓度水平与左心房大小的相关性。结果 在转复成功组患者血浆RAS水平显著低于转复未成功组（P<0.01、 P<0.05）；血浆RAS水平与左心房直径呈显著正相关（P<0.01）。结论 对血浆RAS水平升高的持续性心房颤动患者，胺碘酮转复不易成功。
Abstract:
AIM To probe the effects of renin, angiotensin and aldosterone(RAS) levels on the sinus rhythm restoration in patients with persistent atrial fibrillation. METHODS The sinus rhythm was restored in 36 patients with persistent atrial fibrillation using oral amiodarone and according to the result, all these patients were divided into two groups: restored group (n=19) and unrestored group (n=17). The plasma concentrations of RAS of the two groups were compared and their correlation to the left atrium diameter was also studied. RESULTS The concentrations of RAS in the restored group were significantly lower than those in the unrestored group (P<0.01, P<0.05). The concentrations of RAS were correlated significantly with the diameter of the left atrium (P<0.01). CONCLUSION It is relatively difficult to restore the sinus rhythm by orally taking amiodarone in atrial fibrillation patients with high levels of RAS.

参考文献/References

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［5］ 王学东，贾三庆，胡大一,等. 心房颤动患者循环血浆肾素、血管紧张素II和醛固酮的变化及临床意义［J］. 中国心血管杂志，2004，9（5）：339-341.

［6］ Goette A, Staack T, Rocken C, et al. Increased expression of extracellularsignal regulated kinase and angiotensinconverting enzyme in human atria during atrial fibrillation［J］. J Am Coll Cardiol, 2000,35(6):1669-1677.

［7］ Li D, Shinagawa K, Pang L，et al. Effects of angiotensinconverting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacinginduced congestive heart failure［J］.Circulation,2001, 104(21) : 2608-2614.

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备注/Memo

备注/Memo:
收稿日期：2006-02-22.作者简介：贾新未，副主任医师 Tel：(0312)5981551 Email：jxw1967@yahoo.com.cn
更新日期/Last Update: