我们的网站为什么显示成这样？

可能因为您的浏览器不支持样式，您可以更新您的浏览器到最新版本，以获取对此功能的支持，访问下面的网站，获取关于浏览器的信息：

|本期目录/Table of Contents|

通心络对高血压大鼠血管内皮功能的保护作用(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第5期
页码:
550-552
栏目:
临床研究
出版日期:
2006-10-25

文章信息/Info

Title:
Protective effect of Tongxinluo on blood vessel endothelin in hypertensive rats
作者:
葛华1; 赵英莉2; 王璇1; 陈雷1
1.沈阳医学院奉天医院心内科， 辽宁 沈阳 110024；2.沈阳水泵厂医院
Author(s):
GE Hua;  ZHAO Ying-li;  WANG Xuan;  CHEN Lei
Department of Cardiology, Fengtian Hospital Affiliated to Shenyang Medical College, Shengyang,Liaoning 110024, China
关键词:
高血压; 大鼠; 通心络; 内皮功能
Keywords:
hypertension;  rat;  tongxinluo;  endothelium function
分类号:
R544.1
DOI:
-
文献标识码:
A
摘要:
目的 探讨通心络对高血压大鼠血管内皮的保护作用。方法 实验动物分为3组，自发性高血压大鼠（SHR）组，SHR服用通心络（TXL）组和正常血压大鼠（WKY）组。通过放免及聚合酶链反应检测主动脉一氧化氮（NO）、内皮素（ET1）、血管内皮生长因子（VEGF）基因表达。结果 SHR组NO水平低于WKY组（P<0.05），TXL组NO水平高于SHR组（P<0.05）。SHR组ET1含量及mRNA均高于WKY组（P<0.05），TXL组ET1含量及mRNA表达低于SHR组（P<0.05），SHR组及TXL组的mRNA表达均高于WKY组（P<0.05），以SHR组为最高。结论 通心络可能对高血压大鼠的内皮功能有保护作用。
Abstract:
AIM To investigate the protective effect of Tongxinluo on the vascular endothelium of hypertensive rats. METHODS Two groups of twenty male spontaneously hypertensive rats (SHR) were studied: ten with the Tongxinluo therapy (TXL group) and ten without any treatment (SHR group). Another one group of ten male homogeneously healthy rats were used as normal control (WKY group). The radioimmunological assay and reverse transcriptionpolymerase chain reaction (RTPCR) were used to measure the concentration of NO, ET1 and VEGF in aortic walls and gene expression respectively. RESULTS The NO level in SHR group was lower than that in WKY group and the NO level in TXL group was higher than that in SHR group（P<0.05）. The concentration of ET1 and gene expression in SHR group were higher than that in WSK group （P<0.05）and the concentration of ET1 and gene expression in TXL group were lower than those in SHR group （P<0.05）. The gene expression in SHR group was the highest, followed by that in TXL group and then that in WKY group. CONCLUSION Tongxinluo may have some protective effects on vascular endothelium of hypertensive rats.

参考文献/References

［1］ McAllister AS, Atkinston AB, Johnston GD, et al. Relationship of endothelial function to birth weight in humans［J］. Diabetes Care, 1999, 22(12):2061-2062.

［2］ Taddei S, Virdis A, Mattei P, et al. Defectivel Largininenitric oxide pathway in offspring of essential hypertension patients［J］. Circulation, 1996, 94(6):1298-1303.

［3］ Fortepiani LA, Rodrigo E, Ortiz MC, et al. Pressure natriuresis in nitric oxidedificient hypertensive rat: effect of antihypertensive treatment［J］. Am Soc Nephrol, 1999, 10(1):21-27.

［4］ Jamali AH, Tang WH, Khot UN, et al. The role of angiotensin receptor blockers in the management of chronic heart failare［J］. Arch Intern Med, 2001, 161(5):667-672.

［5］ Zubkov AY, Ogigara K, Tumu P, et al. Bloody cerebrospinal fluid alters contractility of cultrured arteries［J］. Neurol Res, 1999, 21(6):553-558.

［6］ Yue TL, Gu JL, Wang C, et al. Extracellular,signalrequlation kinase plays an essential role in hypertrophic agonists,endothlin1 and phenylephrineinduced cardiomyocyte hypertrophyts ［J］. J Biol Chem, 2000, 275(48):37895-37901.

［7］ Kohno M, Murakawa K, Horio T, et al. Plasma immunoreactive endothelin1 in experimental malignant hypertension［J］. Hypertension, 1991, 18（1）:93-100.

［8］ Hernandezperara O,PerezSala D,NavarroAntolin J, et al. Effects of the 3hydroxy3 methylglutarylCoA reductasenhibitors, atovastain and simvastatin, on theex oression of endotheli1 andendothelial nitric oxide synthase in vascularen dothelialells［J］. J Clin Invest, 1998, 101(12):2711-2719.

备注/Memo

备注/Memo:
收稿日期：2005-04-18.作者简介：葛华，主任医师，教授，博士 Tel：(024)82262866
更新日期/Last Update: