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阿托伐他汀对不稳定型心绞痛患者IL-18和超敏CRP的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第5期
页码:
556-558
栏目:
临床研究
出版日期:
2006-10-25

文章信息/Info

Title:
The effect atorvastatin on interleukin-18 and high sensitive C-reactive protein levels in patients with unstable angina pectoris
作者:
莫云秋; 黄洁; 卫智权; 庞伦祥
广西中医学院附属瑞康医院心内科 ， 广西 南宁 530011
Author(s):
MO Yun-qiu;  HUANG Jie; WEI Zhi-quan; PANG Lun-xiang
Department of Cardiology, Ruikang Hospital Affiliated to Guangxi Traditional Chinese Medicine College, Nanning ，Guangxi 530011,China.
关键词:
阿托伐他汀; 不稳定型心绞痛; 白细胞介素18; 超敏C反应蛋白
Keywords:
atorvastatin;  unstable angina pectoris;  interleukin-18;  high sensitive C-reactive protein
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨阿托伐他汀对不稳定型心绞痛（UAP）患者白细胞介素18 （IL-18）和超敏C反应蛋白（hs-CRP）的影响及其量效关系。 方法 UAP患者60例，按数字表法随机分为：阿托伐他汀20 mg组30例，每天口服阿托伐他汀20 mg，共4周；40 mg组30例，每天口服阿托伐他汀40 mg，共4周；分别于治疗前和治疗后测定血清IL-18和hs-CRP水平，比较治疗前和治疗后血清IL18和hsCRP的变化。另设30例健康体检者为对照组。 结果 ①UAP组患者IL18和hsCRP水平显著高于对照组（P<0.01）;②两种剂量阿托伐他汀治疗后患者血清IL-18和hs-CRP水平显著降低（P<0.01）；③治疗后阿托伐他汀40 mg组比20 mg组hs-CRP和IL-18水平下降更显著（P<0.01）。 结论 UAP患者体内存在炎症反应，阿托伐他汀具有抗炎作用，大剂量使用抗炎效果更好，应早期大剂量应用。
Abstract:
AIM To investigate the effect of different dosage of atorvastatin on interleukin-18（IL-18）and high sensitive C-reactive protein（hs-CRP）levels in patients with unstable angina pectoris（UAP）. METHODS Sixty patients with UAP were divided randomly into two groups, the half of the patients receive oral atorvastatin 20 mg every day for 4 weeks, the others receive oral atorvastatin 40 mg every day for 4 weeks. In addition, thirty healthy people are the compared group. The serum levels of IL-18 and hsCRP were detected and compared before and after treatment. RESULTS The serum levels of IL-18 and hsCRP were significantly higher in the patients with UAP than those compared group(P<0.01).The levels of IL-18 and hsCRP were significantly depressed in both atorvastatin 20 mg group and atorvastatin 40 mg group than those group which do not receive oral atorvastatin (P<0.01) ,but these changes were more significant in the atorvastatin 40 mg group than in the atorvastatin 20 mg group(P<0.01). CONCLUSION Inflammatory reaction exists in patients with UAP. Atorvastatin can resist inflammation. The higher dose, the more benefit. Therefore the patients with UAP should receive oral atorvastatin early.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2006-03-29.作者简介：莫云秋，副主任医生，副教授 Tel：（0771）2188103 Email：moyq3785@126.com
更新日期/Last Update: