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内皮素与硝酸甘油的耐药性及阿托伐他汀的影响(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2006年第5期
页码:
559-561，567
栏目:
临床研究
出版日期:
2006-10-25

文章信息/Info

Title:
Endthelin-1 and nitroglycerin tolerance: effect of atorvastatin
作者:
刘继烈1; 李明春1; 田秀芹1; 阎文泰2
1.漯河市中心医院心血管内科, 河南 漯河 462000；2.郑州大学第一附属医院心血管内科, 河南 郑州 450052
Author(s):
LIU Ji-lie1;  LI Ming-chun1;  TIAN Xiu-qin1;  YAN Wen-tai2
1.Department of Cardiology, Central Hospital of Luohe City, Luohe, Henan 462000, China; 2.Department of Cardiology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052 China
关键词:
硝酸甘油; 耐药性; 内皮素-1; 阿托伐他汀
Keywords:
nitroglycerin;  tolerance;  endthelin-1;  atorvastatin
分类号:
R311.3
DOI:
-
文献标识码:
A
摘要:
目的 观察阿托伐他汀对硝酸甘油(nitroglycerin,NTG)耐药性的影响，并对其作用机制进行初步探讨。方法 雄性SD大鼠随机分成4组(n=8)，戊巴比妥钠（50 mg/kg）麻醉后，取心室内血液2 ml测内皮素-1(endthelin-1,ET-1)含量，并取胸主动脉用于检测血管组织ET1含量及用于动脉环实验，测出最大舒张反应百分率，绘出浓度效应曲线，测出舒张50%时NTG的浓度值。结果 ①动脉环的最大舒张反应：耐药+他汀组与耐药组相比显著增强(P<0.01)，耐药+他汀组与对照组相比差异也有显著性(P<0.01)。②舒张50%时的NTG的浓度值：耐药+他汀组与耐药组相比显著减小(P<0.01)，耐药+他汀组与对照组相比差异也有显著性(P<0.01)。③浓度效应曲线：耐药+他汀组与耐药组相比显著左移，耐药+他汀组与对照组﹑他汀组相比浓度效应曲线右移。④耐药组血管壁组织内ET1浓度及血浆内ET1浓度与对照组、他汀组和耐药+他汀组相比显著升高(P<0.01)，而对照组、耐药+他汀组间相比差异显著(P<0.01)，对照组、他汀组间相比差异无统计学意义。结论 阿托伐他汀可改善NTG的耐药性，但并不能完全逆转NTG的耐药现象。
Abstract:
AIM To assess the effects of atorvastatin on the development of tolerance during continuous transdermal nitroglycerin therapy and to investigate its mechanism. METHODS Thirtytwo health male SpragueDawley rats were randomly divided into four groups, with 8 rats in each group. The rats were sacrificed by pentobarbitone sodiun（50 mg/kg）and used for vascular rings experiment. The contents of ET1 in vasculature or blood plasma were measured. When the contractions had reached a stable plateau, relaxation responses to nitroglycerin (0.001-100 μmol/L) were obtained to draw a density effect curve and test the density value of 50% of its own maximal response. RESULTS The maximal relaxation responses in tolerance + statin group were significantly stronger than those in tolerance group (P<0.01). There was significant difference between tolerance + statin group and control group (P<0.01). The value of 50% nitroglycerin responses in tolerance + statin group were significantly weaker than those in tolerance group (P<0.01). There was significant difference between tolerance + statin group and control group (P<0.01). The density effect curve in tolerance + statin group moved significantly to the left than that in tolerance group. The densityeffect curve in tolerance + statin group moved to the right compared with that in tolerance group or statin group. The contents of ET1 in tolerance group were significantly higher than those in control group, statin group and tolerance + statin group in vasculature or plasma (P<0.01), with significant difference between tolerance + statin group and control group (P<0.01). There was no significant difference between statin group and control group . CONCLUSION Atorvastatin therapy restores nitroglycerin tolerance, but can not completely restore nitroglycerin tolerance.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2005-06-16.通讯作者：刘继烈，主治医师，主要从事冠心病的诊治研究 Tel：（0395）2686907
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