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PPARγC161T基因多态性与冠脉粥样硬化的相关性(PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第4期
页码:
431-433
栏目:
临床研究
出版日期:
2007-08-01

文章信息/Info

Title:
Relationship between peroxisome proliferators activated receptor gamma C161T gene polymorphism and coronary artery atherosclerosis
作者:
张英梅1; 李兰荪1; 陆松鹤2; 苏海霞2; 沈敏1; 张殿新1; 王海昌1
第四军医大学：1.西京医院心内科， 2.军事预防医学系流行病学教研室，陕西 西安 710032
Author(s):
ZHANG Yingmei;  LI Lansun;  LU Songhe;  SU Haixia;  SHEN Min;  ZHANG Dianxin;  WANG Haichang
Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi′an 710033, Shaanxi, China
关键词:
冠状动脉粥样硬化; 过氧化物酶体增殖物激活受体; 基因多态性
Keywords:
coronary artery atherosclerotic;  peroxisome proliferators activated receptor;  gene polymorphism
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 明确冠状动脉硬化患者过氧化物酶体增殖物激活受体 γ(PPARγ)C161T基因多态性与冠状动脉狭窄的关系。方法 检测161例冠状动脉硬化患者和103名正常对照的血压、体质量指数(BMI)、腰围、血脂、空腹血糖(FBG)、餐后2h血糖(2hBG)，聚合酶链反应限制性片断多态性方法测定PPARγ C161T基因多态性。结果 冠状动脉硬化组腹围、显著高于对照组(P<0.01)。2 h BG亦高于对照组（P<0.05）,冠状动脉硬化组PPARγ CC型显著高于对照组(P<0.05)，CT型显著低于对照组（P<0.01）。结论 PPARγ C161T与冠状动脉粥样硬化有关联。
Abstract:
AIM To study whether PPARγ C161T polymorphism was associated with coronary artery atherosclerosis. METHODS Polymerase chain reaction restricted fragments length polymorphism was used to study the distribution of the PPARγ C161T polymorphism in 161 coronary heart disease (CHD) patients and 103 normal controls. RESULTS Waistline was significantly higher in CHD patients compared with those in control (P<0.01) while 2 h BG was significantly higher in CHD patients (P<0.05). The frequencies of the CC were significantly higher in CHD compared with those in control (P<0.05) while the frequencies of the CT were significantly lower in CHD patients (P<0.01). CONCLUSION PPARγ C161T polymorphism is associated with genesis and development of coronary artery atherosclerosis.

参考文献/References

［1］ Marx N, Sukhova G, Murphy C,et al. Macrophages in human atheroma Contain PPARγ:differentiationdependent peroxisomal proliferatorsactivated Receptorγ(PPARγ)expression and reduction of MMP9 activity through PPARγ activated in mononuclear phagocyte in vitro［J］.Am J Pathol, 1998,153(1):17-23.

［2］ Law R E, Goetze S, Xi XP,et al. Expression and function of PPARγ in rat and human vascular smooth muscle cells［J］.Circulation,2000,101(11):1311-1318.

［3］ Doney A,Fischer B,Frwe D,et al. Haplotype analysis of the PPARγ Pro12Ala and C1431T variants reveals opposing associations with body weight［J］. BMC genet,2002, 3:21.

［4］ Lei HH, Chen MH, Yang WS,et al. Peroxisome proliferatorsactivated receptor gamma Pro12Ala gene variant is strongly associated with larger bodyss in the Taiwanese［J］. Metabolism, 2000,49(10): 1267-1270.

［5］ Weiss EP. Endurance traininginduced changes in the insulin response to oral glucose are associated with the peroxisome proliferatoractivated receptorgamma 2 Pro12Ala genotype in men but not in women［J］. Metabolism,2005, 54(1):97-102.

［6］ Schneider J,Kreuzer J,Hamann A, The proline 12 alanine substitution in the peroxisome proliferatoractivated receptor gamma 2 gene is associated with lower lipoprotein lipase activity in vivo［J］. Dlabetes,2002, 51 (3): 867-870.

［7］ 闫振成 祝之明 沈成义,等 代谢综合征PPARγ C161T基因多态性与颈动脉损害的相关研究［J］. 中华医学杂志，2004，84(7)：543-547.

［8］ Pischon T, Pai J K, Manson J E,et al. Peroxisome proliferatoractivated receptorγP12A polymorphism and risk of coronary heart diseasein US men and women［J］. Arterioscler Thromb Vasc Biol, 2005 ,25(8):1654-1658.

备注/Memo

备注/Memo:
收稿日期：2006-10-12.通讯作者：李兰荪，主任医师，教授，主要从事冠心病的诊断及治疗研究Email:Lilansun@sina.com作者简介：张英梅，住院医师，硕士生Email：zhangym197951@126.com
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