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普鲁布考对急性冠脉综合征患者血浆oxLDL、炎症因子的干预效应 (PDF)

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2007年第4期
页码:
434-437
栏目:
临床研究
出版日期:
2007-08-01

文章信息/Info

Title:
Effects of Probucol in plasma oxLDL and hsCRP in patients with acute coronary syndrome
作者:
董红梅 黄岚宋耀明晋军耿召华宋明宝武晓静于世勇
第三军医大学新桥医院全军心血管研究所,重庆 400037
Author(s):
DONG Hongmei HUANG Lan SONG Yaoming JIN Jun GENG Zhaohua SONG Mingbao WU Xiaojing YU Shiyong
Institute of Cardiology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China
关键词:
冠状动脉疾病氧化低密度脂蛋白炎症介导素类
Keywords:
coronary syndrome oxidative low density lipoprotein inflammation mediators
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 观察普罗布考对急性冠脉综合征(ACS)患者血浆氧化低密度脂蛋白(oxLDL)、肿瘤坏死因子α(TNFα)及高敏C反应蛋白(hsCRP)干预效应。方法 ACS患者51例,随机分为两组,普罗布考组(P组)和常规治疗组(C组),检测外周血oxLDL、TNFα、hsCRP,用药治疗3月,观察治疗前后指标变化。 结果 治疗后P组相对于C组oxLDL、TNFα及hsCRP浓度降低明显。P组治疗后血浆oxLDL水平与TNFα、hsCRP均为正相关。结论 普罗布考可降低oxLDL、TNFα及hsCRP,具有抗氧化、抗炎作用。
Abstract:
AIM To observe the effects of Probucol in plasma oxidative low density lipoprotein, tumornecrosis factorα and high sensitivity Creactive protein in patients with acute coronary syndrome (ACS). METHODS Fiftyone ACS patients were divided randomly into a Probucol treatment group (P) and a conventional treatment group (C). Oxidized lowdensity lipoprotein (oxLDL), tumornecrosis factorα (TNFα) and high sensitivity Creactive protein (hsCRP) were respectively measured in peripheral blood. These variables were analyzed after a 3month Probucol treatment. RESULTS The levels of oxLDL, TNFα and HsCRP were significantly higher in ACS patient. There was a significantly positive correlation between the level of oxLDL, TNFα, hsCRP and the degree of ACS. The levels of oxLDL and TNFα, hsCRP decreased significantly after a 3 month treatment and more significantly in the Probucol group than those in the conventional group. The linear correlation analysis showed that plasma oxLDL was positively correlated with hsCRP and TNFα after Probucol treatment in ACS patients. CONCLUSION oxLDL, TNFα and hsCRP increase remarkably in ACS patients and are correlated with the degree of CHD.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期:2006-06-23 基金项目:国家自然科学基金项目资助(No.30470729)通信作者:黄岚,教授,主任医师,主要从事血管内皮的损伤及修复与冠心病防治的研究Email:huanglans@21cn.com 作者简介:董红梅,主治医师,硕士Email:hmdong@126.com
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