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|本期目录/Table of Contents|

依那普利与地尔硫卓治疗心脏X综合征疗效的比较

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第1期
页码:
79
栏目:
临床研究
出版日期:
2009-02-28

文章信息/Info

Title:
Comparison of enalapril and diltiazem in treating patients with cardiac X-syndrome
作者:
吴培堂; 母翠萍; 邵素美
单县中心医院心内科,济宁医学院附属湖西医院心内科,山东 单县 274300
Author(s):
WU Pei-tang;  MU Cui-ping;  Shao Su-mei
Department of Cardiology, Central Hospital, Shan County; Department of Cardiology, Huxi Hospital, Jining Medical College, Shan County 274300, Shandong, China
关键词:
依那普利; 地尔硫卓; X综合征; 冠状动脉血流储备; 内皮素-1; 一氧化氮
Keywords:
enalapril;  diltiazem;  X-syndrome;  coronary flow reserve;  nitric oxide;  endothelln-1
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 观察应用依那普利与地尔硫卓治疗心脏X综合征（CSX）患者的疗效。 方法 将43例心脏X综合征患者随机接受依那普利 (21例,依那普利组) 或地尔硫卓(22例,地尔硫卓组)治疗，随访治疗3个月后的临床情况并复查平板运动试验、冠状动脉血流储备（CFR）及一氧化氮（NO）、血浆内皮素-1（ET-1）的含量。结果 与本组治疗前比较，用药3个月后两组胸痛例数及最大ST段压低幅度明显减少，ET-1水平明显下降，CFR及NO的水平明显升高，运动总时间、ST段压低1 mm时间明显延长（P<0.01或P<0.05）。与地尔硫卓组相比，依那普利组胸痛例数及最大ST段压低幅度明显减少 (均为P<0.05)，ET-1水平明显下降（P<0.01），CFR及NO的水平明显升高(均为P<0.05)，运动总时间、ST段压低1 mm时间明显延长（P<0.01,P<0.05）。结论 依那普利与地尔硫卓均能改善CSX患者的内皮细胞功能提高患者的运动耐量及CFR，且依那普利较地尔硫卓更为有效。
Abstract:
AIM To investigate the therapeutic effects of enalapril and diltiazem on patients with cardiac X-syndrome. METHODS Forty-three patients with cardiac X-syndrome were randomly allocated to be treated by enalapril (Group A, n=21) and diltiazem (Group B, n=22) for three months. The clinical presentations, results of treadmill tests, coronary flow reserve (CFR), and the levels of endothelin-1(ET-1) and nitrooxide (NO) were compared before and three months after treatment. RESULTS After the 3-month therapy, chest pain, ST depression and the levels of ET-1 significantly decreased and CFR, the levels of NO significantly increased and total exercise duration, time to 1 mm ST segment depression were significantly longer (P<0.01 or P<0.05, vs before treatment) in the two groups. Chest pain, ST depression and the levels of ET-1 significantly decreased, CFR and the levels of NO significantly increased (all P<0.05 vs diltiazem group) and total exercise duration and time to 1 mm ST segment depression were significantly longer (all P<0.05 vs diltiazem group) in enalapril group. CONCLUSION Enalapril may have a better effect than diltiazem in the improvement of exercise tolerance for the patients with cardiac X-syndrome.

参考文献/References

[1］ Wagner AH, Kohler T, Ruckschloss U, et al. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation［J］. Arterioscler Thromb Vasc Biol, 2000, 20(1):61-69.
［2］ Griendling KK, Minieri CA, Ollerenshaw JD, et al. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells［J］. Circ Res, 1994, 74(6):1141-1148.
［3］ Kaski JC, Russo G. Microvascular angina in patients with syndrome X［J］. Z Kardiol, 2000, 89 Suppl 9:121-125.
［4］ Noto N, Karasawa K, Ayusawa M, et al. Measurement of coronary flow reserve in children by transthoracic Doppler echocardiography［J］. Am J Cardiol, 1997, 80(12):1638-1639.
［5］ 陈在嘉,徐义枢. 临床冠心病学［M］. 北京:人民军医出版社, 1994:106-107.
［6］ Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress［J］. Circ Res, 2000, 87(10):840-844.
［7］ Yamamoto S, James TN, Kawamura K, et al. Cardiocytic apoptosis and capillary endothelial swellingas morphological evidence of myocardial ischemia in ventricular biopsies from patients with angina and normal coronary arteriograms［J］. Coronary Artery Disease, 2002, 13(1):25-35.
［8］ Chen JW, Hsu NW, Wu TC, et al. Long-term angiotensin- converting enzyme inhibition reduces plasma asymmetric dimethylarginine and improves endothelial nitric oxide bioavailability and coronary microvascular function in patients with syndrome X［J］. Am J Cardiol, 2002, 90(9):974-982.
［9］ Pizzi C, Manfrini O, Fontana F, et al. Angiotensin-converting enzyme inhibitors and 3-hydroxy-3-methylglutaryl coenzyme A reductase in cardiac Syndrome X: role of superoxide dismutase activity［J］. Circulation, 2004, 109(1):53-58.

备注/Memo

备注/Memo:
收稿日期：2007-12-19.作者简介：吴培堂，副主任医师Email:wpt8881@163.com
更新日期/Last Update: 2009-04-02