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|本期目录/Table of Contents|

血浆SDF-1α、TGF-β1水平与不同类型冠心病患者和冠状动脉狭窄程度的相关性

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第2期
页码:
220
栏目:
临床研究
出版日期:
2009-03-30

文章信息/Info

Title:
Correlation between serum levels of SDF-1α and TGF-β1 and degree of coronary artery stenosis in patients with different types of coronary artery disease
作者:
张文宗1; 张守彦2; 何燕1; 沈琳1; 林钟香1
1.上海中医药大学附属龙华医院心内一科,上海200032；2.北京军区总医院心肺血管中心，北京 100700
Author(s):
ZHANG Wen-zong1;  ZHANG Shou-yan2;  HE Yan1;  SHEN Lin1;  LIN Zhong-xiang1
1.First Department of Cardiology, Longhua Hospital Affiliated to University of Shanghai Traditional Chinese Medicine, Shanghai 200032, China; 2.Center of Heart and Pulmonary Vessels, General Hospital, Beijing Military Area Command, Beijing 100700, China
关键词:
血浆基质细胞衍生因子-1α、转化生长因子-β1; 冠状动脉疾病; 相关性
Keywords:
stromal cell derived factor-1α;  transforming growth factor-β1;  coronary disease;  correlation
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 探讨血浆基质细胞衍生因子-1α（SDF-1α）、转化生长因子-β1 (TGF-β1)与不同类型冠心病和冠心病冠脉狭窄程度的相关性。方法 124 例患者分为:稳定型心绞痛（SAP）组32例、不稳定型心绞痛（UAP）组30例、急性心肌梗死（AMI）组32例及对照组30 例。ELISA法测定血浆SDF-1α、TGF-β1水平；并冠脉造影，用Gensini积分评定冠状动脉狭窄程度。结果 ①血浆SDF-１α、TGF-β1水平SAP组、UAP组、AMI组低于对照组(P<0.01)，UAP组、AMI组低于SAP组(P<0.01)，AMI 组低于UAP组(P<0.01)；②血浆SDF-1α水平与SAP组、UAP组、AMI组Gensini积分的相关系数分别为:r=-0.31，P=0.0749；r=-0.69，P=0.0036；r=-0.76，P=0.0049；TGF-β1与各组Gensini积分的相关系数分别为：r=-0.19，P=0.1592；r=-0.71，P=0.0037；r=-0.77，P=0.0029；③血浆SDF-1α、TGF-β1水平在单支病变、双支病变和三支病变组间差异显著(P<0.01)，与病变血管支数成负相关（r=-0.65，P=0.0218；r=-0.73，P=0.0065）。结论 冠心病患者血浆SDF-1α、TGF-β1水平降低，与冠心病严重程度及冠状动脉狭窄程度呈负相关。
Abstract:
AIM To explore the correlation between the serum levels of SDF-1α and TGF-β1 and different types of coronary artery diseases as well as the degree of stenosised coronary artery. METHODS A total of 124 patients were divided into four groups: 32 cases were diagnosed as stable angina pectoris (SAP), 30 cases as unstable angina pectoris (UAP), 32 cases as acute myocardial infarction (AMI), and a control group of 30 cases who had been identified by as having no coronary diseases by coronary angiography. The serum level of SDF-1α and TGF-β1 were determined by ELISA assay and following coronary angiography, the degree of coronary artery stenosis was determined by Gensini’s scores system. RESULTS ① The serum levels of SDF-1α and TGF-β1 in each coronary heart disease group were significantly lower than those in control group (P<0.01). The levels in UAP and AMI groups were lower than in those in SAP group (P<0.01) and the levels in AMI group were lower compared with those the UAP group (P<0.01). ②The correlation indexes in UAP, SAP and AMI groups were respectively -0.31 (P=0.0749), -0.69(P=0.0036) and -0.76(P=0.0049) between the serum levels of SDF-1α and the coronary artery Gensini’s scores. The correlation indexes in UAP, SAP and AMI groups were respectively -0.19(P=0.1529), -0.71(P=0.0037) and -0.77(P=0.0029) between the serum level of TGF-β1 and the coronary artery Gensini’s scores. ③The serum levels of SDF-1α and TGF-β1 were significantly different between unicoronary artery stenosis, bicoronary artery stenosis and tricoronary artery stenosis (P<0.01), and the serum levels of SDF-1α and TGF-β1 were negatively correlated with the number of stenosised coronary artery（r=-0.65, P=0.0218； r=-0.73, P=0.0065）. CONCLUSION The serum levels of SDF-1α and TGF-β1 in the coronary heart disease group are lower than those in the control group and are negatively correlated with the severity of coronary artery disease and the stenosised degree of coronary arteries.

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备注/Memo

备注/Memo:
收稿日期：2008-8-29.基金项目：上海市教委博士点基金赞助项目资助 （200782） 通讯作者：林钟香，主任医师，主要从事心内科疾病的临床及科研工作Email:Linzhongxiang@Hotmail.com 作者简介：张文宗，主治医师，博士Email:zhangwenzong601@163.com
更新日期/Last Update: 2009-04-16