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|本期目录/Table of Contents|

冠心病患者血脂蛋白(α)水平及其临床意义

《心脏杂志》[ISSN:1009-7236/CN:61-1268/R]

期数:
2009年第2期
页码:
224
栏目:
临床研究
出版日期:
2009-03-30

文章信息/Info

Title:
Change of serum lipoprotein(α) in coronary heart disease and its significance
作者:
李爱英
内蒙古医学院附属医院心内科，内蒙古 呼和浩特010050
Author(s):
LI Ai-ying
Department of Cardiovascular Disease, First Affiliated Hospital, Nei Mongol Medical College, Hohhot 010050, Nei Mongol, China
关键词:
冠状动脉疾病; 脂蛋白(α); 预后; 危险因素
Keywords:
coronary heart disease;  lipoprotein(α);  prognosis;  risk factors
分类号:
R541.4
DOI:
-
文献标识码:
A
摘要:
目的 观察血清脂蛋白(α)［LP(α)］水平与冠心病（CHD）类型、病变和预后的关系。方法 将CHD患者（95例）分为3组：急性心肌梗死（AMI）组30例，不稳定型心绞痛（UAP）组35例及稳定型心绞痛（SAP）组30例。取血测定LP(α)。对CHD患者在住院期间及出院1个月内进行观察，观察终点为主要急性心脏事件（MACE）。结果 ①当按CHD不同临床类型比较时,发现UAP与AMI组LP(α)水平与MACE发生率均显著高于SAP组(P<0.05或P<0.01),但UAP与AMI组差异未达到显著水平；②当按LP(α)水平分组比较时,≥300 mg/L组多支病变和MACE的发生率均显著高于LP(α)<300 mg/L组(均P<0.01)。结论 LP(α)水平与CHD的严重程度有关，并与CHD预后相关。
Abstract:
AIM To investigate the changes of serum lipoprotein(α) ［LP(α)］ as well as the relationship with the types and severity of coronary lesions and the prognosis in coronary heart diseases（CHD）. METHODS Patients with CHD (95 cases) were divided into three groups: acute myocardial infarction (AMI) group of 30 cases, unstable angina pectoris (UAP) group of 35 cases and stable angina pectoris (SAP) group of 30 cases. The levels of LP(α) of the three groups were compared and then the patients were followed up for 1 month. The end point was main acute cardiac events. RESULTS ①In terms of different clinical types of CHD, the level of LP(α) and the occurrence rate of MACE in UAP group and AMI group were significantly higher than those in SAP group (P<0.05), but no significant difference was found between UAP group and AMI group. ②In terms of LP(α) levels, the coronary lesions of multiple branches and the occurrence rate of MACE in the group of more than 300mg/L were significantly higher than those in the group of less than 300 mg/L (P<0.01). CONCLUSION The level of LP(α) is positively correlated with the severity of coronary lesions and the prognosis of CHD.

参考文献/References

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备注/Memo

备注/Memo:
收稿日期：2008-9-8.作者简介：李爱英，主治医师，硕士Email：hhhtlay＠sina.com
更新日期/Last Update: 2009-04-16